α-Methyltryptamine
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α-Methyltryptamine (abbreviated as αMT, AMT) is a
Chemistry
αMT is a tryptamine with a
Synthesis
The synthesis of αMT can be accomplished through several different routes, the two most widely known being the Nitroaldol Condensation between
Pharmacology
αMT acts as a relatively balanced
MAOI activity
αMT has been shown as a
In rats the potency of αMT as an MAO-A inhibitor in the brain was approximately equal to that of
Metabolism
2-Oxo-αMT, 6-hydroxy-αMT,[16] 7-hydroxy-αMT and 1′-hydroxy-αMT were detected as metabolites of αMT in male Wistar rats .[17]
Dosage and effects
Under the trade name Indopan, 5-10 milligrams were used for an antidepressant effect.[medical citation needed]
With 20–30 milligrams,
Neurologic side effects of αMT include agitation, restlessness, confusion, and lethargy. Physical manifestations including
Side effects self-reported by recreational users include
Legality
Australia
The 5-Methoxy analogue,
China
As of October 2015 αMT is a controlled substance in China.[22]
Denmark
In Denmark (2010), the Danish Minister for the Interior and Health placed αMT to their lists of controlled substances (List B).[23]
Canada
Canada has no mention of αMT in the Controlled Drugs and Substances Act.[24]
Germany
αMT is listed under the Narcotics Act in schedule 1 (narcotics not eligible for trade and medical prescriptions) in Germany.[23]
Austria
αMT is placed under Austrian law (NPSG) Group 6.[23]
Hungary
αMT was controlled on the Schedule C list in Hungary in 2013.[23]
Slovakia
αMT was placed in 2013 on the List of Hazardous Substances in Annex, § 2 in Slovakia.[23]
Slovenia
αMT appeared on the Decree on Classification of Illicit Drugs in Slovenia (2013).[23]
Lithuania
In Lithuania (2012), αMT is controlled as a tryptamine derivative put under control in the 1st list of Narcotic Drugs and Psychotropic Substances which use is prohibited for medical purposes.[23]
Spain
αMT is legal in Spain.[25]
Sweden
Sveriges riksdags health ministry Statens folkhälsoinstitut classified αMT as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Mar 1, 2005, in their regulation SFS 2005:26 listed as alfa-metyltryptamin (AMT), making it illegal to sell or possess.[26]
United Kingdom
αMT was made illegal in the United Kingdom as of 7 January 2015, along with 5-MeO-DALT.[27] This was following the events of 10 June 2014 when the Advisory Council on the Misuse of Drugs recommended that αMT be scheduled as a class A drug by updating the blanket ban clause on tryptamines.[28]
United States
The Drug Enforcement Administration (DEA) placed αMT temporarily in schedule I of the Controlled Substances Act (CSA) on April 4, 2003, pursuant to the temporary scheduling provisions of the CSA (68 FR16427). On September 29, 2004, αMT was permanently controlled as a schedule I substance under the CSA (69FR 58050).[29]
Finland
AMT, alfa-methyltryptamine is a controlled drug in Finland[30]
Reported deaths
αMT is capable of causing life-threatening side-effects including
See also
- 4-Methyl-αMT
- 5-Fluoro-αMT
- 5-MeO-αMT
- α-Ethyltryptamine
- α,N-DMT
- α,N,N-TMT
- α-Methyl-5-HT
Notes
References
- ^ a b c "Erowid AMT Vault : FAQ by Dialtonez".
- ^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
- ^ a b c "Erowid Online Books : "TIHKAL" - #48 a-MT".
- ^ "Erowid AMT (alpha-methyltryptamine) Vault".
- ^ US Patent 3296072, Szmuszkovicz Jacob, "Method of Treating Mental Depression", published 1967-01-03, assigned to Upjohn Co
- ISBN 978-0-471-72760-6.
- ISBN 978-1-4613-4045-4.
- ISBN 978-0-12-398360-2.
- ^ Anonymous. "TheHive". Retrieved 7 June 2023.
- ^ Shulgin A. "TIHKAL". Retrieved 18 May 2018.
- PMID 17223101.
- PMID 18057721.
- PMID 3747266.
- PMID 13851725.
- ^ PMID 13898151.
- S2CID 27030395.
- S2CID 20637936.
- S2CID 38340985.
- ^ PMID 16105268.
- ^ "Erowid AMT Vault : Effects".
- ^ "Erowid 5-MeO-AMT Vault : Legal Status".
- ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
- ^ a b c d e f g "Reference at www.who.int" (PDF).
- ^ "CSDA". Archived from the original on 2011-09-28. Retrieved 2011-06-05.
- ^ "Medicamentos de Uso Humano - Estupefacientes y Psicótropos". Agencia Española de Medicamentos y Productos Sanitarios. Archived from the original on 2019-01-02. Retrieved 2019-01-01.
- ^ "Förordning om ändring i förordningen (1999:58) om förbud mot vissa hälsofarliga varor;" (PDF), Lagen om förbud mot vissa hälsofarliga varor - SFS 2005:26 (in Swedish), February 2005, archived from the original (PDF) on 2013-09-29, retrieved 2013-10-07
- ^ "The Misuse of Drugs (Amendment No. 3) (England, Wales and Scotland) Regulations 2014". www.legislation.gov.uk.
- ^ ACMD (10 June 2014). "Update of the Generic Definition for Tryptamines" (PDF). UK Home Office. p. 12. Retrieved 10 June 2014.
- ^ "Alpha-methyltryptamine" (PDF). DEA Office of Diversion Control. April 2013. Archived (PDF) from the original on 2013-10-17. Retrieved 2013-10-10.
- ^ "Reference at www.finlex.fi" (PDF).
- PMID 16051647. "drugs such as MDMA, ecstasy (3,4-methylenedioxymethamphetamine), if combined with MAOIs (including moclobemide) do also cause fatalities because they act as serotonin releasers"
- ^ "Call for ban on drug after reveller's death". Western Gazette. March 22, 2012. Archived from the original on 2013-10-16. Retrieved October 1, 2013.
- ^ "Southampton 'legal high' death deemed 'accidental'". BBC News. 2013-11-12. Retrieved 2013-11-19.