β-Thromboglobulin
| β-Thromboglobulin | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | Chr. 4 q13.3 | ||||||
| |||||||
β-Thromboglobulin (β-TG), or beta-thromboglobulin, is a
platelet activation.[1][4][5] As a result, they are useful markers of platelet activation.[1][4] β-TG also has multiple biological activities, for instance being involved in maturation of megakaryocytes.[6]
Biological actions
β-TG is a
glucose metabolism, and plasminogen activator synthesis in human fibroblasts.[5]
β-TG also affects megakaryocyte maturation, and thus helps in regulating platelet production.[5]
Clinical uses
Levels of β-TG is used to index platelet activation. It is measured by ELISA in blood plasma or urine, and often in conjunction with PF4.[5]
Influences
β-TG levels may increase with age.diabetes mellitus.[8]
β-TG levels have been found to be increased by treatment with the
natural estrogen estradiol valerate.[9][10][11][12] Levels of β-TG have also been found to be increased or unchanged during normal pregnancy.[13]
References
- ^ S2CID 23686294.
- PMID 6160890.
- PMID 16391012.
- ^ S2CID 58519828.
- ^ a b c d Cytokines & Cells Online Pathfinder Encyclopaedia → Beta-Thromboglobulin Retrieved on August 17, 2009
- OCLC 1006915388.
- S2CID 34486553.
- ISBN 0-86542-871-9.
- S2CID 205931204.
- PMID 9198173.
- ISBN 9781850709565.
- PMID 2526387.
- PMID 12709915.