Beta-actin
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Β-actin
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| Location (UCSC) | Chr 7: 5.53 – 5.56 Mb | Chr 5: 142.89 – 142.89 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Actin beta (HUGO Gene Nomenclature Committee abbreviation ACTB/ACTB) is one of six different
cytoskeletal actins. Actins are highly conserved proteins[5][6] that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.[7]
Interactions
Actin beta has been shown to
Sam68 was found to interact with the mRNA encoding actin beta, which regulates the synaptic formation of the dendritic spines with its cytoskeletal components.Actin beta has been shown to activate eNOS, thereby increasing NO production. An eight-amino acid motif (326-333) in eNOS has been shown to mediate the interaction between actin and eNOS.[10]
Clinical relevance
Recurrent mutations in this gene have been associated to cases of diffuse large B-cell lymphoma.[11]
Applications
Actin beta is often used in
qPCR. Its molecular weight is approximately 42 kDa.[citation needed
]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000075624 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029580 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 25788699.
- PMID 6842590.
- ^ "Entrez Gene: ACTB actin, beta".
- S2CID 4323027.
- PMID 11461920.
- PMID 19946124.
- PMID 22343534.
External links
- Human ACTB genome location and ACTB gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P60709 (Actin, cytoplasmic 1) at the PDBe-KB.
Further reading
- Vandekerckhove J, Leavitt J, Kakunaga T, Weber K (1980). "Coexpression of a mutant beta-actin and the two normal beta- and gamma-cytoplasmic actins in a stably transformed human cell line". Cell. 22 (3): 893–9. S2CID 54299848.
- Leavitt J, Gunning P, Porreca P, Ng SY, Lin CS, Kedes L (1984). "Molecular cloning and characterization of mutant and wild-type human beta-actin genes". Molecular and Cellular Biology. 4 (10): 1961–9. PMID 6095033.
- Ng SY, Gunning P, Eddy R, Ponte P, Leavitt J, Shows T, Kedes L (1985). "Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes". Molecular and Cellular Biology. 5 (10): 2720–32. PMID 3837182.
- Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biologica. 42 (5): 227–30. S2CID 7617882.
- Gunning P, Weinberger R, Jeffrey P (Apr 1997). "Actin and tropomyosin isoforms in morphogenesis". Anatomy and Embryology. 195 (4): 311–5. S2CID 9692297.
- Kimura T, Hashimoto I, Nishikawa M, Fujisawa JI (1997). "A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression". Biochimie. 78 (11–12): 1075–80. PMID 9150887.
- Szentirmay MN, Sawadogo M (May 2000). "Spatial organization of RNA polymerase II transcription in the nucleus". Nucleic Acids Research. 28 (10): 2019–25. PMID 10773068.
- Anderson JL, Hope TJ (Apr 2004). "HIV accessory proteins and surviving the host cell". Current HIV/AIDS Reports. 1 (1): 47–53. S2CID 34731265.
- Pederson T, Aebi U (Nov 2005). "Nuclear actin extends, with no contraction in sight". Molecular Biology of the Cell. 16 (11): 5055–60. PMID 16148048.
- Perrin BJ, Ervasti JM (Oct 2010). "The actin gene family: function follows isoform". Cytoskeleton. 67 (10): 630–4. PMID 20737541.
See also
- Actin
- ACTA1
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