1-Pyrroline-5-carboxylate dehydrogenase
| 1-pyrroline-5-carboxylate dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In
enzymology, a 1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) is an enzyme that catalyzes the chemical reaction
- (S)-1-pyrroline-5-carboxylate+ NAD+ + 2 H2O L-glutamate + NADH + H+
The three
substrates of this enzyme are (S)-1-pyrroline-5-carboxylate, NAD+, and H2O, whereas its three products are glutamate, NADH, and H+
.
This enzyme belongs to the family of
glutamate metabolism and arginine and proline metabolism
.
Structural studies
As of late 2007, 14
structures have been solved for this class of enzymes, with PDB accession codes 2BHP, 2BHQ, 2BJA, 2BJK, 2EHQ, 2EHU, 2EII, 2EIT, 2EIW, 2EJ6, 2EJD, 2EJL, 2IY6, and 2J40
.
Human gene
In human, the protein is encoded by ALDH4A1 gene.
References
- Adams E, Goldstone A (December 1960). "Hydroxyproline metabolism. IV. Enzymatic synthesis of gamma-hydroxyglutamate from Delta 1-pyrroline-3-hydroxy-5-carboxylate". The Journal of Biological Chemistry. 235 (12): 3504–12. PMID 13681370.
- Strecker HJ (1960). "The interconversion of glutamic acid proline. III Delta1-Pyrroline-5-carboxylic acid dehydrogenase". J. Biol. Chem. 235: 3218–3223. .
