11β-Hydroxysteroid dehydrogenase type 1

Source: Wikipedia, the free encyclopedia.

HSD11B1
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_181755
NM_001206741
NM_005525

NM_001044751
NM_008288

RefSeq (protein)

NP_001038216
NP_032314

Location (UCSC)Chr 1: 209.69 – 209.73 MbChr 1: 192.9 – 192.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

11β-Hydroxysteroid dehydrogenase type 1, also known as cortisone reductase, is an

adipose tissue, and the central nervous system. In these tissues, HSD11B1 reduces cortisone to the active hormone cortisol that activates glucocorticoid receptors. It belongs to the family of short-chain dehydrogenases. It is encoded by the HSD11B1 gene
.

Function

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Two transcript variants encoding the same protein have been found for this gene.[5]

Cortisol-cortisone equilibrium
Cortisol-cortisone equilibrium

Clinical significance

11β-HSD1 is inhibited by

glycyrrhiza glabra was discovered as an inhibitor.[6]

HDAC inhibitors that alter genetic expression. EGCG as usually consumed in green tea is poorly absorbed into the bloodstream. More research is needed to reach firm conclusions.[citation needed
]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117594 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016194 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1".
  6. S2CID 21938309
    .
  7. .
  8. .

External links

Further reading