1976 swine flu outbreak
1976 H1N1 swine influenza outbreak | |
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United States of America | |
First outbreak | Fort Dix, New Jersey |
Date | 1976 |
Hospitalized cases | 13 |
Deaths | 1 |
In 1976, an outbreak of the swine flu, influenza A virus subtype H1N1 at Fort Dix, New Jersey caused one death, hospitalized 13, and led to a mass immunization program. After the program began, the vaccine was associated with an increase in reports of Guillain–Barré syndrome (GBS), which can cause paralysis, respiratory arrest, and death. The immunization program was ended after approximately 43 millions United States citizens had been administered the vaccine.[1]
Richard Krause, director of the National Institute of Allergy and Infectious Diseases from 1975 to 1984, writes that the government response to the swine flu outbreak was considered to be too fast.[2] The Centers for Disease Control and Prevention states, "Those who received the 1976 swine flu vaccine had a slight increased risk for developing GBS of approximately one additional case of GBS for every 100,000 people who got the swine flu vaccine."[3]
Chronology
This chronology is heavily influenced by the official history of the affair, published in 1978 by the National Academies Press: The Swine Flu Affair: Decision-Making on a Slippery Disease.[4]
In January 1976, several soldiers at
The Center for Disease Control (now the Centers for Disease Control and Prevention) verified the findings and informed both the World Health Organization and the state of New Jersey. On February 13, CDC Director David Sencer completed a memo calling for mass immunization for the swine flu. The CDC Assistant Director for Programs of the Center for Disease Control, Bruce Dull, held a press conference on February 19[5] to discuss the flu outbreak at Fort Dix and, in response to questions from reporters, mentioned the relationship of the flu strain to the 1918 outbreak.[6]
U.S. President
The House Appropriations Committee reported out a special appropriations bill, including $135 million for the swine flu immunization program, which was approved on April 5. Two days later, the World Health Organization held a conference to discuss the implications of a swine flu outbreak for poorer nations.[4]
On April 8, an official from the
Bruce Dull stated at a flu conference on July 1 that there were no parallels between the 1918 flu pandemic and the current situation. Later that month, J. Anthony Morris, a researcher in the
In early August, an outbreak of illness in Philadelphia was thought to be related to swine flu.[11] It was later found to be an atypical pneumonia that is now called Legionnaires' disease. On August 6, Ford held a press conference and urged Congress to take action on the indemnification legislation. Four days later, both houses of Congress passed the legislation.[4]
Merrill became the first company to submit samples to the FDA's Bureau of Biologics for safety testing, which approved it on September 2. Merck made the first shipment of vaccines to state health departments by September 22. The first swine flu inoculations were given at a health fair in Indianapolis, Indiana.[12] Immunization started nationwide the next day.
In October, three people died of heart attacks after they had received the vaccine at the same Pittsburgh clinic, which sparked an investigation and the recall of that batch of vaccine. The investigation showed that the deaths were not related to the immunization. The President and his family received their immunizations before the television cameras.[13] On November 2, Ford lost the presidential election to Jimmy Carter.[4]
Also in early November, Albert Sabin published a New York Times editorial, "Washington and the Flu."[14] He agreed with the decision to create the vaccine and to be prepared for an outbreak but criticized the "scare tactics" that had been used by Washington to achieve that. He suggested to stockpile the vaccine and to have a wait-and-see strategy.[4]
By 15 December, cases of
A summarizing study concludes "that vaccination overall is of public health benefit, helping to reduce mortality and prevent the thousands of deaths that occur from annual seasonal outbreaks, despite the possibility of an increased risk of GBS". In total, GBS cases occurred in 362 patients during the six weeks after influenza vaccination of 45 million persons.[16]
Aftermath
External videos | |
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Booknotes interview with Gina Kolata on Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It, February 27, 2000, C-SPAN |
Laurence Gostin, in his article "At Law: Swine Flu Vaccine: What Is Fair?",[17] wrote that "the swine flu affair fails to tell us whether, in the face of scientific uncertainty, it is better to err on the side of caution or aggressive intervention." There is not even complete agreement about the causal relationship between the swine flu vaccine and Guillain-Barré syndrome, as noted in Gina Kolata's book Flu: The Story of the Great Influenza Pandemic of 1918 and the Search for the Virus That Caused It.[18] She wrote that the CDC did not have a "specific set of tests and symptoms to define Guillain-Barré" and that since doctors who reported cases already knew that a link was suspected, a bias in reporting was introduced. She quoted Keiji Fukuda: "if a new virus gets identified or reappears, you don't want to jump the gun and assume a pandemic is happening."[18]
See also
- COVID-19 pandemic
- 1918-19's Spanish flu
- 2009 swine flu pandemic
- 1976 Philadelphia Legionnaires' disease outbreak
References
- CDC. Retrieved 2024-02-01.
- PMID 16494715.
- ^ Centers for Disease Control and Prevention (25 August 2021). "GBS (Guillain-Barré Syndrome) and Vaccines | Vaccine Safety | CDC". www.cdc.gov. Archived from the original on 17 January 2022. Retrieved 6 January 2022.
- ^ from the original on January 3, 2019. Retrieved November 10, 2017.
- ProQuest 122565338.
- ^ Schmeck, Harold M. Jr. (February 20, 1976). "U.S. Calls Flu Alert On Possible Return Of Epidemic's Virus". The New York Times. p. 1.
- ProQuest 122583791.
- ProQuest 134035690.
- ^ Posner, Gerald (2 March 2020). "Big Pharma May Pose an Obstacle to Vaccine Development". The New York Times. Archived from the original on 7 March 2020. Retrieved 10 April 2020.
- ^ Fisher, Richard (22 September 2020). "The fiasco of the 1976 'swine flu affair'". BBC. Archived from the original on 27 December 2020. Retrieved 19 December 2020.
- ProQuest 122608464.
- ^ "First Flu Shots Friday", The New York Times, September 30, 1976, p. 16
- ProQuest 538320129.
- ^ Sabin, Albert (November 5, 1976). "Washington and the Flu". New York Times: 21.
- ProQuest 171470249.
- PMID 22582208.
- S2CID 30868245.
- ^ ISBN 0374157065.
External links
- Media related to 1976 swine flu outbreak at Wikimedia Commons