1V-LSD

Source: Wikipedia, the free encyclopedia.
1V-LSD
Clinical data
Routes of
administration
oral
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
  • UK: PSA
Illegal in Sweden and South Korea.
Identifiers
  • (6aR,9R)-N,N-Diethyl-7-methyl-4-pentanoyl-4,,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
JSmol)
  • CCN(CC)C(=O)[C@@H]5C=C2[C@@H](Cc3cn(C(=O)CCCC)c4cccc2c34)N(C)C5
  • InChI=1S/C25H33N3O2/c1-5-8-12-23(29)28-16-17-14-22-20(19-10-9-11-21(28)24(17)19)13-18(15-26(22)4)25(30)27(6-2)7-3/h9-11,13,16,18,22H,5-8,12,14-15H2,1-4H3/t18-,22-/m1/s1
  • Key:GIIBVGJWUZNECE-XMSQKQJNSA-N

1V-LSD (1-valeryl-D-lysergic acid diethylamide), sometimes nicknamed Valerie, is a

analogue of LSD.[3]
1V-LSD has been sold online until an amendment to the German NpSG was enforced in 2022 which controls 1P-LSD and now 1cP-LSD, 1V-LSD and several other lysergamides.[4]

Pharmacology

As demonstrated with other N-

acylated derivatives of LSD, 1V-LSD is believed to serve as a prodrug for LSD but may also act as a weak partial agonist at the 5-HT2A receptor.[3]

Animal studies

A Head-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and 1cP-LSD, with behavioral effects also closely resembling these structural analogs.[5]

Chemistry

1V-LSD is the condensation product of valeric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of the indole moiety.[6] Ehrlich's reagent is used to identify the presence of an indole moiety; the chemical backbone of the lysergamide and ergoline molecules.[7] However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn't fresh.[8][9]

Legal position

1V-LSD is not a controlled substance in North America (United States and Canada), unless sold for human consumption in the US.[10]

Since March 2nd 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled.

1V-LSD was placed under legal control in South Korea in July 2022 on a temporary but renewable basis.[11]

An amendment to the NpSG banned the sale of 1V-LSD in Germany in September 2022. Due to a interpunctation error in the actualised NpSG, the ban never took effect.[12] The law was amended in March 2023, now banning 1V-LSD.

1v-LSD strip blotters

See also

References

  1. ^ "1V-LSD (solution)". www.caymanchem.com.
  2. ^ "1V-LSD PsychonautWiki". Psychonautwiki.
  3. ^
    PMID 34837347
    .
  4. ^ "1V-LSD - legales LSD 3.0". YouTube (in German).
  5. PMID 31756337
    .
  6. .
  7. .
  8. ^ "REACTIONS 1V-LSD". 16 July 2021.
  9. ^ "1V-LSD reaction with the ehrlich reagent". 16 July 2021.
  10. ^ 21 U.S. Code § 813 - Treatment of controlled substance analogues
  11. ^ Kim Chan-hyuk, Regulator names 1V-LSD as narcotic drug temporarily. Korea Biomedical Review, 5 July 2022
  12. ^ "Gesetzespanne: Gefährliche LSD-Derivate plötzlich legal".


This page is based on the copyrighted Wikipedia article: 1V-LSD. Articles is available under the CC BY-SA 3.0 license; additional terms may apply.Privacy Policy