1V-LSD
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1V-LSD (1-valeryl-D-lysergic acid diethylamide), sometimes nicknamed Valerie, is a
1V-LSD has been sold online until an amendment to the German NpSG was enforced in 2022 which controls 1P-LSD and now 1cP-LSD, 1V-LSD and several other lysergamides.[4]Pharmacology
As demonstrated with other N-
Animal studies
A Head-twitch response assay in mice found that 1V-LSD has a similar potency to 1P-LSD and 1cP-LSD, with behavioral effects also closely resembling these structural analogs.[5]
Chemistry
1V-LSD is the condensation product of valeric acid (pentanoic acid) and LSD, where the valeroyl group is substituted on the NH position of the indole moiety.[6] Ehrlich's reagent is used to identify the presence of an indole moiety; the chemical backbone of the lysergamide and ergoline molecules.[7] However, as with other N-acylated lysergamides, 1V-LSD reacts very slowly to Ehrlich reagent and may not give reliable results if the reagent isn't fresh.[8][9]
Legal position
1V-LSD is not a controlled substance in North America (United States and Canada), unless sold for human consumption in the US.[10]
Since March 2nd 2022, 1V-LSD has been under investigation in Sweden and may therefore soon become controlled.
1V-LSD was placed under legal control in South Korea in July 2022 on a temporary but renewable basis.[11]
An amendment to the NpSG banned the sale of 1V-LSD in Germany in September 2022. Due to a interpunctation error in the actualised NpSG, the ban never took effect.[12] The law was amended in March 2023, now banning 1V-LSD.
See also
References
- ^ "1V-LSD (solution)". www.caymanchem.com.
- ^ "1V-LSD PsychonautWiki". Psychonautwiki.
- ^ PMID 34837347.
- ^ "1V-LSD - legales LSD 3.0". YouTube (in German).
- PMID 31756337.
- PMID 27767302.
- S2CID 97915487.
- ^ "REACTIONS 1V-LSD". 16 July 2021.
- ^ "1V-LSD reaction with the ehrlich reagent". 16 July 2021.
- ^ 21 U.S. Code § 813 - Treatment of controlled substance analogues
- ^ Kim Chan-hyuk, Regulator names 1V-LSD as narcotic drug temporarily. Korea Biomedical Review, 5 July 2022
- ^ "Gesetzespanne: Gefährliche LSD-Derivate plötzlich legal".