3-hydroxy-2-methylbutyryl-CoA dehydrogenase
| 3-hydroxy-2-methylbutyryl-CoA dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In
enzymology, a 3-hydroxy-2-methylbutyryl-CoA dehydrogenase (EC 1.1.1.178) is an enzyme that catalyzes the chemical reaction
- (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ 2-methylacetoacetyl-CoA + NADH + H+
Thus, the two
.This enzyme belongs to the family of
valine, leucine and isoleucine degradation
.
Structural studies
As of 20 January 2010, 6
structure have been solved for this class of enzymes, with the PDB accession code 1E3S, 1E3W, 1E6W, 1SO8, 1U7T, 2O23
.
References
- Conrad RS, Massey LK, Sokatch JR (1974). "D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida". J. Bacteriol. 118 (1): 103–11. PMID 4150713.
