3CLpro-1

3CLpro-1
Clinical data
Trade names	3CLpro-1
Legal status
Legal status	US: Investigational drug;
Identifiers
	IUPAC name (2S)-2-[[(E)-3-(4-chloro-2-fluorophenyl)prop-2-enoyl]amino]-N-[(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl]-3-phenylpropanamide;
JSmol)	Interactive image;
	SMILES C1CNC(=O)[C@@H]1C[C@@H](C=O)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)/C=C/C3=C(C=C(C=C3)Cl)F;
	InChI InChI=1S/C25H25ClFN3O4/c26-19-8-6-17(21(27)14-19)7-9-23(32)30-22(12-16-4-2-1-3-5-16)25(34)29-20(15-31)13-18-10-11-28-24(18)33/h1-9,14-15,18,20,22H,10-13H2,(H,28,33)(H,29,34)(H,30,32)/b9-7+/t18-,20-,22-/m0/s1; Key:HXAHMXYAYHWWRI-ZCTWNQIISA-N;

3CLpro-1 is an

nM. It also shows activity against coronavirus diseases such as SARS and MERS, and is under investigation as a potential treatment agent for the viral disease COVID-19.^[1]^[2]^[3]^[4]^[5]^[6]^[7]

References

PMID 18583140
.

PMID 25666761
.

PMID 28216367
.

PMID 32226821
.

PMID 32022370
.

PMID 32045235
.

PMID 32198291
.

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[1] PMID 18583140
.

[2] PMID 25666761
.

[3] PMID 28216367
.

[4] PMID 32226821
.

[pmid32022370-5] PMID 32022370
.

[6] PMID 32045235
.

[7] PMID 32198291
.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

See also

References