4-686-293-01
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Names | |
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IUPAC name
1,10-Bis[(3-dimethylcarbamoxy-α-picolinyl)ethylamino]decane dimethobromide
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Other names
Agent 1-10
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Identifiers | |
3D model (
JSmol ) |
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Properties | |
C34H58N6O4 · Br2 | |
Molar mass | 774.678 g/mol |
Appearance | white crystalline solid |
Melting point | 173–176 °C (343–349 °F; 446–449 K) |
Solubility | soluble in water and alcohols |
Hazards | |
NFPA 704 (fire diamond) | |
Lethal dose or concentration (LD, LC): | |
LD50 (median dose)
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11 μg/kg (intravenous, mouse) 4 μg/kg (intravenous, rabbit) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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4-686-293-01, also known as Agent 1-10, is a highly potent experimental
Physical properties
4-686-293-01 is an odorless crystalline white solid at high purities, whereas impure varieties can present with a brown, light-yellow crystalline structure with an "oily" smell. Due to its high molecular mass and low evaporation rate, 4-686-293-01 can persist in the environment for extremely long periods of time. Agent 1-10 readily dissolves in alcohol and water. The claimed median lethal dose through inhalation in an "average man" is quoted as 320-900 micrograms. Inhalation, ingestion, or eye/skin absorption of as little as 5 to 50 micrograms can lead to incapacitation. The agent has no irritation effects upon inhalation or eye/skin absorption.[4]
Synthesis
The chemical synthesis is performed in an inert nitrogen atmosphere in a
The synthesis occurs in three major steps:
- Preparation of 2-{[ethyl(methyl)amino]methyl}pyridin-3-ol
- Preparation of (3-dimethylcarbamoxy-α-picolinyl)-methyl-ethylamine
- Preparation of 4-686-293-01 agent
The overall synthesis process takes 5–6 days in laboratory conditions.[1][4]