4-Dimethylaminophenol

Source: Wikipedia, the free encyclopedia.
Not to be confused with 4-Dimethylaminopyridine.
4-Dimethylaminophenol
Names
Preferred IUPAC name
4-(Dimethylamino)phenol
Identifiers
3D model (
JSmol
)
ChemSpider
ECHA InfoCard
 100.009.642 Edit this at Wikidata
UNII
  • InChI=1S/C8H11NO/c1-9(2)7-3-5-8(10)6-4-7/h3-6,10H,1-2H3 checkY
    Key: JVVRCYWZTJLJSG-UHFFFAOYSA-N checkY
  • InChI=1/C8H11NO/c1-9(2)7-3-5-8(10)6-4-7/h3-6,10H,1-2H3
    Key: JVVRCYWZTJLJSG-UHFFFAOYAU
  • Oc1ccc(N(C)C)cc1
Properties
C8H11NO
Molar mass 137.179 g/mol
Boiling point 165 °C (329 °F; 438 K) (0.040 bar)
Pharmacology
V03AB27 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

4-Dimethylaminophenol (DMAP) is an aromatic compound containing both phenol and amine functional groups. It has the molecular formula C8H11NO.

Uses

4-Dimethylaminophenol has been used as an antidote for cyanide poisoning.[1] It has also been shown to be effective in treating hydrogen sulfide toxicity.[2]

It works by generating methemoglobin.[3]

This is suitable as an emergency treatment only; treatment must be followed up with

cobalamin
.

In an animal model, it has shown effectiveness when given

Intravenous injection is recommended in a dose of 250 mg.[5]

See also

References

  1. S2CID 32892580
    .
  2. PMID 23111938
    . Retrieved 2023-10-08.
  3. S2CID 36140034
    .
  4. PMID 1922842
    .
  5. ^ Federation of American Scientists (1 February 1996). NATO HANDBOOK ON THE MEDICAL ASPECTS OF NBC DEFENSIVE OPERATIONS (PDF). p. 334.
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