4-HO-MET
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Other names | 3-(2-(ethyl(methyl)amino)ethyl)-1H-indol-4-ol; 4-Hydroxy-N-methyl-N-ethyltryptamine |
Legal status | |
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4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine, metocin, or methylcybin) is a lesser-known
Effects
Users report similar effects to psilocin, including mydriasis, closed and open eye visuals, euphoria, time dilation and general change in thought processes.[2][3] These effects occur in a wavelike pattern such as that of psilocybin with near-normal perception and high effect varying rapidly. The effects last for about 4–6 hours after oral administration.[2][4]
Pharmacology
Pharmacodynamics
Binding sites | Binding affinity Ki (μM)[5] |
---|---|
5-HT1A | 0.228 |
5-HT2A | 0.057 |
5-HT2C | 0.141 |
D1 | >25 |
D2 | 4 |
D3 | 6.7 |
α1A | 9.7 |
α2A | 2.4 |
TAAR1 | 3.1 |
H1 | 0.82 |
SERT | 0.2 |
DAT | >26 |
NET | 13 |
Drug prohibition laws
Sweden
The Swedish Riksdag added 4-HO-MET to Schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012, published by Medical Products Agency in their regulation LVFS 2012:6.[6]
United Kingdom
4-HO-MET is a class A drug in the UK, as a result of the tryptamine catch-all clause.[citation needed]
United States
4-HO-MET is not scheduled at the federal level in the United States, but it is possible that it could be considered an analogue of psilocin, in which case purchase, sale, or possession could be prosecuted under the Federal Analogue Act.[7]
It is a schedule I substance in some states, such as South Dakota[8] and West Virginia.[9]
Germany
4-HO-MET is ruled under the Neue-psychoaktive-Stoffe-Gesetz (NpSG) since July 18, 2019. Production and Import with intent to distribute is punishable. Possession is forbidden but not punishable, although ordering it in small quantities can still be seen as an intent to distribute it and be punished.[citation needed]
See also
- Psychedelics, dissociatives and deliriants
- 4-HO-DET
References
- ^ "§ 54.1-3446. Schedule I." Virginia Law. Retrieved 29 October 2023.
- ^ a b c d Shulgin A, Shulgin A (September 1997). "#47 MIPT". Isomer Design. Transform Press. Retrieved 28 November 2023.
- PMID 31909513.
- S2CID 25483726.
- S2CID 6685927.
- ^ "Föreskrifter om ändring i Läkemedelsverkets föreskrifter (LVFS 2011:10) om förteckningar över narkotika" [Regulations on changes in the Swedish Medicines Agency's regulations (LVFS 2011:10) on lists of narcotics] (PDF) (in Swedish). Elanders Sverige AB. 2012-04-20. Archived from the original (PDF) on 2013-09-28. Retrieved 2014-02-25.
- ^ "21 U.S. Code § 841 - Prohibited acts A", LII / Legal Information Institute, retrieved 2016-08-02
- ^ "Chapter 34-20B Drugs and Substances Control". South Dakota Legislature. Retrieved 2023-10-09.
- ^ "Chapter 60A. Uniform Controlled Substances Act". West Dakota Legislature. Retrieved 2023-10-09.