5-IT
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5-(2-Aminopropyl)indole (5-API, 5-IT, PAL-571)
Chemistry
Although 5-IT is a
Pharmacology
5-IT acts as a
Dosage and effects
Alexander Shulgin wrote briefly about 5-IT in TiHKAL saying: "at 20 milligrams orally, [it] is a long-lived stimulant producing increased heart-rate, anorexia, diuresis, and slight hyperthermia for about twelve hours."[6] As 5-IT is not a tryptamine and thus not within the scope of the book, it is not discussed in any more detail than this.
The following symptoms can indicate 5-IT has been ingested:
It is a MAOI, and when combined with a contraindicated substance, it can lead to death.Deaths
5-IT has been attributed to 14 deaths of people in Sweden since its discovery.
Legality
- 5-IT is a positional isomer of Controlled Substance Actin the US. (The Federal Analog Act includes a clause concerning the effects of the substance as well.)
- 5-IT was banned as a temporary class drug in June 2013, along with 9 other related compounds.[10] On March 5, 2014, the UK Home Office announced that 5-API would be made a class B drug on 10 June 2014 alongside every other benzofuran entactogen and many structurally related drugs.[11]
- 5-IT is covered by the Australian analogue act as an analogue of MDA "by the replacement of up to 2 carbocyclic or heterocyclic ring structures with different carbocyclic or heterocyclic ring structures".[12]
- A formal application for 5-IT to be made illegal in Sweden was made on July 26, 2012, but did not come into effect immediately.
- 5-IT was made illegal in Denmark on 30 September 2012.
- 5-IT is an Anlage I controlled drug in Germany.
- The European Commission published a proposal for a decision calling upon its member states to take measures to control 5-(2-aminopropyl)indole. It asked member states to introduce control measures and criminal penalties as provided under their national legislation covering psychotropic substances.[13]
See also
- 6-IT
- 6-APB
- αMT
References
- PMID 24796848.
- ^ FR 1344579, Hofmann, Albert; Troxler, Franz, "Nouveaux derives de l'indole et leur preparation"
- ^ PMID 24634984.
- PMID 26362361.
- PMID 24115740.
- ISBN 978-0-9630096-9-2. Retrieved 2012-02-08.
- ^ "Nätdrog dödade 14 unga män". Aftonbladet (in Swedish). 28 July 2012.
- S2CID 19956476.
- ^ "Fem nya ämnen klassas som narkotika" (in Swedish). The Swedish National Institute of Public Health. Retrieved 10 September 2015.
- ^ "Temporary class drug order report on 5-6APB and NBOMe compounds". UK Home Office. 4 Jun 2013. Retrieved 2013-07-11.
- ^ UK Home Office (2014-03-05). "The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014". UK Government. Retrieved 2014-03-11.
- ^ "Criminal Code Act 1995" (PDF). Australian Government. 2009-08-05. Retrieved 2012-02-08.
PAGE 503
- ^ "COM(2013) 436 final" (PDF). European Commission. 2013-06-25. Retrieved 2013-06-26.