5-Methoxytryptamine
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5-Methoxytryptamine (5-MT), also known as mexamine, is a
derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels.[1] It is biosynthesized via the deacetylation of melatonin in the pineal gland.[1]
5-MT acts as a
5-HT5A
receptor is unknown.
Measured affinity for some receptors (incomplete list):
- 5-HT1B receptors (Ki = 35 nM) [10]
- 5-HT1D receptors (Ki = 7.3 nM)[11]
- 5-HT1E receptors (Ki = 3151 nM)[12]
- 5-HT1F receptors (Ki = 1166 nM)[13]
- 5-HT2A receptors (Ki = 295 nM)[14]
- 5-HT2B receptors (Ki = 16.4 nM)[15]
- 5-HT2C receptors (Ki = 52.48 nM) [16]
- 5-HT4 receptors (Ki = 501.18 nM)[17]
- 5-HT6 receptors (Ki = 69.18 nM)[18]
- 5-HT7 receptors (Ki = 5.01 nM)[19]
See also
- 2-Methyl-5-hydroxytryptamine
- 5-Benzyloxytryptamine
- 5-Carboxamidotryptamine
- α-Methyl-5-hydroxytryptamine
References
- ^ PMID 2460575.
- S2CID 21620262.
- PMID 9128844.
- PMID 9016931.
- ^ S2CID 24743785.
- S2CID 41813873.
- PMID 10051134.
- ^ Glennon RA, Dukat M, Westkaemper RB (2000-01-01). "Serotonin Receptor Subtypes and Ligands". American College of Neurophyscopharmacology. Archived from the original on 21 April 2008. Retrieved 2008-04-11.
- ISBN 978-1-58829-568-2.
- ^ S. Nigra / Domenech T, et al., 1997
- ^ Cortex / PEROUTKA ET AL., 1989
- ^ Cloned / ZGOMBICK JM, ET AL., 1992
- ^ Cloned / Adham N, et al., 1992
- ^ Cortex / HOYER ET AL., 1987
- ^ Cortex / WAINSCOTT DB, ET AL., 1996
- ^ Cloned / BONHAUS DW, ET AL., 1997
- ^ Caudate / ANSANAY H, ET AL.,1996
- ^ Cloned / Hirst WD, et.al.,2003
- ^ Cloned / BOESS FG, ET AL., 1994