5F-PB-22

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5F-PB-22
Legal status
Legal status
Identifiers
  • 1-Pentyfluoro-1H-indole-3-carboxylic acid 8-quinolinyl ester
JSmol)
  • C1=CC=C2C(=C1)C(=CN2CCCCCF)C(=O)OC3=CC=CC4=C3N=CC=C4
  • InChI=1S/C23H21FN2O2/c24-13-4-1-5-15-26-16-19(18-10-2-3-11-20(18)26)23(27)28-21-12-6-8-17-9-7-14-25-22(17)21/h2-3,6-12,14,16H,1,4-5,13,15H2
  • Key:MBOCMBFDYVSGLJ-UHFFFAOYSA-N

5F-PB-22 (5F-QUPIC or quinolin-8-yl 1-pentyfluoro-1H-indole-3-8-carboxylate) is a

cannabinoid agonist.[2] The structure of 5F-PB-22 appears to have been designed with an understanding of structure–activity relationships within the indole class of cannabinoids.[3]

Pharmacology

5F-PB-22 acts as a

CB2 cannabinoid receptors.[4]

Legal status

As of October 2015 5F-PB-22 is a controlled substance in China.[5]

In January 2014, 5F-PB-22 was designated as a

Schedule I controlled substance in the United States after several deaths were associated with its use.[6][7]

In the United Kingdom, 5F-PB-22 is now classified and controlled as a

Class B drug, following the November 2016 amendment to the Misuse of Drugs Act 1971. Several other synthetic cannabinoids structurally related to JWH-018, like 5F-PB-22, were also classified in this amendment.[8]

See also

References

  1. ^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
  2. PMID 25921407
    .
  3. ^ "5F-PB-22". Forendex. Archived from the original on 27 September 2015. Retrieved 24 June 2015.
  4. PMID 27429655
    .
  5. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
  6. PMID 24876364
    .
  7. PMID 26154784
    .
  8. ^ "The Misuse of Drugs Act 1971 (Amendment) Order 2016". www.legislation.gov.uk. Retrieved 2017-12-20.
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