ACER1

ACER1
Identifiers
Gene ontology
Molecular function	dihydroceramidase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; hydrolase activity; N-acylsphingosine amidohydrolase activity; ceramidase activity; metal ion binding;
Cellular component	membrane; integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum;
Biological process	cellular response to calcium ion; regulation of lipid metabolic process; cell differentiation; sphingosine biosynthetic process; sphingolipid biosynthetic process; response to alkaline pH; keratinocyte differentiation; ceramide metabolic process; epidermis development; lipid metabolism; ceramide catabolic process; sphingolipid metabolic process; regulation of water loss via skin; sebaceous gland development;
	Sources:Amigo / QuickGO

Ensembl


ENSG00000167769


ENSMUSG00000045019


Q8TDN7


Q8R4X1

RefSeq (mRNA)


NM_133492


NM_175731

RefSeq (protein)


NP_597999


NP_783858

Location (UCSC)

PubMed search

^[3]

^[4]

Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene.^[5]

Function

ACER1 mediates cellular differentiation by controlling the generation of sphingosine (SPH) and sphingosine-1-phosphate (S1P).^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167769 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045019 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^
PMID 12783875
.

Human ACER1 genome location and ACER1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.