ADAM33
| ADAM33 | |||
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Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 20: 3.67 – 3.68 Mb | Chr 2: 130.89 – 130.91 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene.[5][6]
Function
This gene encodes a member of the ADAM (
type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness.[7] Alternative splicing of this gene results in two transcript variants encoding different isoforms.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000149451 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027318 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11814695.
- ^ a b "Entrez Gene: ADAM33 ADAM metallopeptidase domain 33".
- PMID 27489884.
Further reading
- Holgate ST, Davies DE, Rorke S, Cakebread J, Murphy G, Powell RM, Holloway JW (August 2004). "ADAM 33 and its association with airway remodeling and hyperresponsiveness in asthma". Clinical Reviews in Allergy & Immunology. 27 (1): 23–34. S2CID 23971367.
- Holloway JW, Davies DE, Powell R, Haitchi HM, Keith TP, Holgate ST (August 2004). "The discovery and role of ADAM33, a new candidate gene for asthma". Expert Reviews in Molecular Medicine. 6 (17): 1–12. S2CID 30427584.
- Holgate ST, Yang Y, Haitchi HM, Powell RM, Holloway JW, Yoshisue H, Pang YY, Cakebread J, Davies DE (July 2006). "The genetics of asthma: ADAM33 as an example of a susceptibility gene". Proceedings of the American Thoracic Society. 3 (5): 440–3. PMID 16799089.
- Van Eerdewegh P, Little RD, S2CID 4424215.
- Garlisi CG, Zou J, Devito KE, Tian F, Zhu FX, Liu J, Shah H, Wan Y, Motasim Billah M, Egan RW, Umland SP (January 2003). "Human ADAM33: protein maturation and localization". Biochemical and Biophysical Research Communications. 301 (1): 35–43. PMID 12535637.
- Chae SC, Yoon KH, Chung HT (2003). "Identification of novel polymorphisms in the Adam33 gene". Journal of Human Genetics. 48 (5): 278–81. PMID 12768445.
- Howard TD, Postma DS, Jongepier H, Moore WC, Koppelman GH, Zheng SL, Xu J, Bleecker ER, Meyers DA (October 2003). "Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations". The Journal of Allergy and Clinical Immunology. 112 (4): 717–22. PMID 14564349.
- Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V (January 2004). "Crystal structure of the catalytic domain of human ADAM33". Journal of Molecular Biology. 335 (1): 129–37. PMID 14659745.
- Zou J, Zhu F, Liu J, Wang W, Zhang R, Garlisi CG, Liu YH, Wang S, Shah H, Wan Y, Umland SP (March 2004). "Catalytic activity of human ADAM33". The Journal of Biological Chemistry. 279 (11): 9818–30. PMID 14676211.
- Powell RM, Wicks J, Holloway JW, Holgate ST, Davies DE (July 2004). "The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts". American Journal of Respiratory Cell and Molecular Biology. 31 (1): 13–21. PMID 14742294.
- Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Wilson DI, Holgate ST, Davies DE (May 2005). "ADAM33 expression in asthmatic airways and human embryonic lungs". American Journal of Respiratory and Critical Care Medicine. 171 (9): 958–65. PMID 15709049.
- Zou J, Zhang R, Zhu F, Liu J, Madison V, Umland SP (March 2005). "ADAM33 enzyme properties and substrate specificity". Biochemistry. 44 (11): 4247–56. PMID 15766253.
- Simpson A, Maniatis N, Jury F, Cakebread JA, Lowe LA, Holgate ST, Woodcock A, Ollier WE, Collins A, Custovic A, Holloway JW, John SL (July 2005). "Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function". American Journal of Respiratory and Critical Care Medicine. 172 (1): 55–60. PMID 15805180.
External links
- The MEROPS online database for peptidases and their inhibitors: M12.244
- Human ADAM33 genome location and ADAM33 gene details page in the UCSC Genome Browser.
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