AM-1241

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AM-1241
Legal status
Legal status
Identifiers
  • (2-Iodo-5-nitrophenyl)-[1-[(1-methylpiperidin-2-yl)methyl]indol-3-yl]methanone
JSmol)
  • Ic2ccc(N(=O)=O)cc2C(=O)c(c4ccccc14)cn1CC3CCCCN3C
  • InChI=1S/C22H22IN3O3/c1-24-11-5-4-6-16(24)13-25-14-19(17-7-2-3-8-21(17)25)22(27)18-12-15(26(28)29)9-10-20(18)23/h2-3,7-10,12,14,16H,4-6,11,13H2,1H3 checkY
  • Key:ZUHIXXCLLBMBDW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

AM-1241 (1-(methylpiperidin-2-ylmethyl)-3-(2-iodo-5-nitrobenzoyl)indole) is a chemical from the

amyotrophic lateral sclerosis in animal models.[8][9]

Effects in bone cancer model

The antihyperalgesic effects of AM-1241 were investigated in a

murine bone cancer model. Sarcoma cells were injected into the femur of a mouse, and then mice were injected twice daily with AM-1241. Treatment with AM-1241 reduced both spontaneous and evoked pain, as well as reducing the bone loss and subsequent fractures due to the tumor. Pretreatment with the CB2 antagonist SR-144,528 reversed the acute effects of AM-1241 on both spontaneous and evoked pain, while having no effect on its own.[10]

See also

References

  1. PMID 16894349
    .
  2. PMID 17549048
    .
  3. PMID 12917492
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  4. PMID 18289088
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  5. S2CID 19266396
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  6. PMID 15705714
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  7. PMID 18234885
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  8. PMID 16781706
    .
  9. PMID 17241118
    .
  10. PMID 20176037
    .
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