AM-2233

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AM-2233
Legal status
Legal status
Identifiers
  • 1-[(N-methylpiperidin-2-yl)methyl]-3-(2-iodobenzoyl)indole
JSmol)
  • Ic3ccccc3C(=O)c1cn(CC2CCCCN2C)c4c1cccc4
  • InChI=1S/C22H23IN2O/c1-24-13-7-6-8-16(24)14-25-15-19(17-9-3-5-12-21(17)25)22(26)18-10-2-4-11-20(18)23/h2-5,9-12,15-16H,6-8,13-14H2,1H3 checkY
  • Key:KSLCYQTUSSEGPT-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

AM-2233 is a drug that acts as a highly potent

radioligand for the cannabinoid receptors and has been used as its 131I derivative for mapping the distribution of the CB1 receptor in the brain.[2][3][4][5][6][7] AM-2233 was found to fully substitute for THC in rats, with a potency lower than that of JWH-018 but higher than WIN 55,212-2.[8]

It is notable for inducing tinnitus,[9] though the reasons for this are unclear and may provide valuable insight into tinnitus research.

Legal Status

As of October 2015 AM-2233 is a controlled substance in China.[10]

See also

References

  1. ProQuest 304624325
    .
  2. PMID 16190764
    .
  3. ISBN 978-3-7643-7055-8
    .
  4. PMID 16438957
    .
  5. S2CID 21269336
    .
  6. PMID 20641836
    .
  7. PMID 19022181
    .
  8. PMID 21836461
    .
  9. ^ "AM-2233 INDUCED TINNITUS: COLLECTED REPORTS". 30 September 2014. Retrieved 5 April 2019.
  10. ^ "关于印发《非药用类麻醉药品和精神药品列管办法》的通知" (in Chinese). China Food and Drug Administration. 27 September 2015. Archived from the original on 1 October 2015. Retrieved 1 October 2015.
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