AM-6545

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AM-6545
Identifiers
  • 5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide
JSmol)
  • O=S4(=O)CCN(CC4)NC(=O)c1nn(-c2ccc(Cl)cc2Cl)c(c1C)-c3ccc(C#CCCC#N)cc3
  • InChI=1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34) checkY
  • Key:XBHQLFVDGLPBCK-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)

AM-6545 is a drug which acts as a peripherally selective

cannabinoid antagonists such as rimonabant have been marketed for this application, but have subsequently been withdrawn from sale because of centrally mediated side effects such as depression and nausea. Because AM-6545 does not cross the blood–brain barrier to any significant extent, it does not produce these kinds of side effects, but has still been shown to effectively reduce appetite and food consumption in animal studies.[1][2][3][4]

See also

  • CB-13 – a peripherally selective cannabinoid agonist
  • O-2050 – a centrally active CB1 silent antagonist
  • mu opioid receptor
    antagonist
  • TM-38837 - another peripherally selective cannabinoid antagonist

References

  1. PMID 20664173
    .
  2. PMID 20713079
    .
  3. PMID 20880401
    .
  4. PMID 21369753
    .
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