AM-938

AM-938
Identifiers
	IUPAC name (6S,6aR,9R,10aR)-9-(Hydroxymethyl)-6-(3-hydroxyprop-1-ynyl)-6-methyl-3-(2-methyloctan-2-yl)-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol;
JSmol)	Interactive image;
	SMILES Oc2cc(cc1O[C@@](C#CCO)([C@@H]3CC[C@H](C[C@H]3c12)CO)C)C(C)(C)CCCCCC;
	InChI InChI=1S/C27H40O4/c1-5-6-7-8-12-26(2,3)20-16-23(30)25-21-15-19(18-29)10-11-22(21)27(4,13-9-14-28)31-24(25)17-20/h16-17,19,21-22,28-30H,5-8,10-12,14-15,18H2,1-4H3/t19-,21-,22-,27+/m1/s1 ; Key:FFRHKSZKZQWCOY-UOTIDGTBSA-N ;
	(what is this?) (verify)

AM-938 (part of the

classical and nonclassical cannabinoid families,^[1] with the 6-hydroxyalkyl chain rigidified with a triple bond. This gives AM-938 a greater degree of selectivity, so while it is still a potent agonist at both CB₁ and CB₂, it is reasonably selective for CB₂, with a K_i of 0.3 nM at CB₂ and 1.2 nM at CB₁, a selectivity of around four-fold.^[2]^[3]

References

ISBN 3-540-22565-X
.

PMID 7776825
.

PMID 9733485
.

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Retrieved from "https://en.wikipedia.org/w/index.php?title=AM-938&oldid=1214845861"

[1] ISBN 3-540-22565-X
.

[2] PMID 7776825
.

[3] PMID 9733485
.

[1]

[2]

[3]

See also

References