AMB-FUBINACA

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AMB-FUBINACA
Legal status
Legal status
Identifiers
  • Methyl (2S)-2-{[1-[(4-fluorophenyl)methyl]indazole-3-carbonyl]amino}-3-methylbutanoate
JSmol)
  • COC([C@H](C(C)C)NC(C1=NN(C2=C1C=CC=C2)CC3=CC=C(F)C=C3)=O)=O
  • InChI=1S/C21H22FN3O3/c1-13(2)18(21(27)28-3)23-20(26)19-16-6-4-5-7-17(16)25(24-19)12-14-8-10-15(22)11-9-14/h4-11,13,18H,12H2,1-3H3,(H,23,26)/t18-/m0/s1
  • Key:FRFFLYJQPCIIQB-SFHVURJKSA-N

AMB-FUBINACA (also known as FUB-AMB and MMB-FUBINACA

CB2 and EC50 values of 0.5433 nM at CB1 and 0.1278 nM at CB2,[4] and has been sold online as a designer drug.[5][6][7][8] It was originally developed by Pfizer which described the compound in a patent in 2009, but was later abandoned and never tested on humans.[9] AMB-FUBINACA was the most common synthetic cannabinoid identified in drug seizures by the Drug Enforcement Administration in 2017 and the first half of 2018.[10]

Mass casualties

On July 12, 2016, the

Brooklyn, New York,[9] where 33 people ranging in age from 25 to 59 years old were adversely affected by the drug.[11] 18 were hospitalized.[11] All of the victims were described by-standers as “zombielike” and the cause was attributed to use of AMB-FUBINACA as the demethylated metabolite was found in the blood and urine of eight of the hospitalized patients that had been sent for testing by the DEA. Screening for the more usual drugs of abuse was negative in all 8 patients. AMB-FUBINACA itself was found in a sample from the product smoked by another patient. The metabolite was identified after 10 days and the AMB-FUBINACA was only confirmed 17 days after the incident.[11]

Around 60 deaths in New Zealand were attributed to either AMB-FUBINACA or a related compound 5F-ADB during 2017–2018, with tested products containing between 32 mg/g and 400 mg/g of the active ingredient, between 2x to 25x stronger than the product involved in the mass casualty event in New York a year earlier.[12][13][14][15]

Legal status

In the United States, AMB-FUBINACA is a

synthetic cannabis product called "Train Wreck 2" which had been linked to adverse events and seizures on 3 June 2014.[17]

Sweden's public health agency suggested classifying AMB-FUBINACA as a hazardous substance on November 10, 2014.[18]

See also

References

  1. ^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
  2. ^ "Substance Details FUB-AMB". Retrieved 2024-01-22.
  3. doi:10.1002/dta.3403
    .
  4. PMID 29549157
    .
  5. ^ "FUB-AMB". Cayman Chemical. Retrieved 21 July 2015.
  6. PMID 26757069
    .
  7. PMID 27421060
    .
  8. PMID 35788413
    .
  9. ^
    ISSN 0362-4331
    . Retrieved 2016-12-15.
  10. S2CID 88290992
    .
  11. ^
    S2CID 205100837
    .
  12. ^ Killer chemicals, Part 1. Stuff.co.nz, September 2017
  13. ^ Worsening synthetic drug crisis demands action. Stuff.co.nz, 18 September 2017
  14. ^ "Synthetic cannabis users gambling with their lives after a 'bad batch'". stuff.co.nz.
  15. ^ "Synthetic cannabis a 'public health emergency' - NZ Drug Foundation | Newshub". Archived from the original on 2018-10-18. Retrieved 2018-10-17.
  16. ^ Controlled Substances listed by the DEA
  17. ^ "DHH Adds Two New Synthetic Marijuana Compounds to Banned List". Louisiana Department of Health and Hospitals. 3 June 2014. Retrieved 21 July 2015.
  18. ^ "Cannabinoider föreslås bli klassade som hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. Retrieved 21 July 2015.
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