AMPA

AMPA

Names
IUPAC name 2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid
Identifiers
CAS Number	74341-63-2 N
3D model ( JSmol )	Interactive image
ChEMBL	ChEMBL276815 N
ChemSpider	1184 Y
DrugBank	DB02057 Y
IUPHAR/BPS	4131
MeSH	AMPA
PubChem CID	1221
CompTox Dashboard (EPA)	DTXSID20868301
InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12) Y Key: UUDAMDVQRQNNHZ-UHFFFAOYSA-N Y InChI=1/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12) Key: UUDAMDVQRQNNHZ-UHFFFAOYAT
SMILES O=C1/C(=C(\ON1)C)CC(N)C(=O)O
Properties
Chemical formula	C7H10N2O4
Molar mass	186.167 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, better known as AMPA, is a compound that is a specific agonist for the AMPA receptor, where it mimics the effects of the neurotransmitter glutamate.^[1]

There are several types of glutamatergic ion channels in the central nervous system including AMPA,

AMPA was first synthesized, along with several other ibotenic acid derivatives, by Krogsgaard-Larsen, Honoré, and others toward differentiating glutamate sensitive receptors from aspartate sensitive receptors.^[3]

See also

• Ampakine

References