ARID1A
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| Location (UCSC) | Chr 1: 26.69 – 26.78 Mb | Chr 4: 133.68 – 133.76 Mb | |||||||
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AT-rich interactive domain-containing protein 1A is a protein that in humans is encoded by the ARID1A gene.[5][6][7]
Function
ARID1A is a member of the
beta-globin locus. Second, the C-terminus of the protein can stimulate glucocorticoid receptor-dependent transcriptional activation. The protein encoded by this gene confers specificity to the SWI/SNF complex and recruits the complex to its targets through either protein-DNA or protein-protein interactions.[8] Two transcript variants encoding different isoforms have been found for this gene.[7]
Clinical significance
Gene encoding for ARID1A is the most frequently mutated SWI/SNF subunit across cancers. In
mTOR inhibitors. These findings provide a rationale for why tumors accumulate ARID1A mutations.[16][17]
Research
Lack of this gene/protein seems to protect rats from some types of liver damage.[18]
Interactions
ARID1A has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000117713 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007880 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 9630625.
- PMID 9434167.
- ^ a b "Entrez Gene: ARID1A AT rich interactive domain 1A (SWI-like)".
- PMID 37788668.
- PMID 38001317.
- S2CID 8884065.
- PMID 27941798.
- PMID 20942669.
- PMID 29136504.
- PMID 38458187.
- PMID 22233809.
- PMID 27172896.
- PMID 28810143.
- ^ "Tissue Regeneration Promoted through Gene Suppression". Genetic Engineering & Biotechnology News. March 2016.
- PMID 11734557.
- ^ PMID 8895581.
- S2CID 3184211.
Further reading
- Martens JA, Winston F (April 2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes". Current Opinion in Genetics & Development. 13 (2): 136–142. PMID 12672490.
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. PMID 8125298.
- Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (September 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes & Development. 10 (17): 2117–2130. PMID 8804307.
- Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, et al. (October 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". The EMBO Journal. 15 (19): 5370–5382. PMID 8895581.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. PMID 9373149.
- Dallas PB, Cheney IW, Liao DW, Bowrin V, Byam W, Pacchione S, et al. (June 1998). "p300/CREB binding protein-related protein p270 is a component of mammalian SWI/SNF complexes". Molecular and Cellular Biology. 18 (6): 3596–3603. PMID 9584200.
- Dallas PB, Pacchione S, Wilsker D, Bowrin V, Kobayashi R, Moran E (May 2000). "The human SWI-SNF complex protein p270 is an ARID family member with non-sequence-specific DNA binding activity". Molecular and Cellular Biology. 20 (9): 3137–3146. PMID 10757798.
- Nie Z, Xue Y, Yang D, Zhou S, Deroo BJ, Archer TK, et al. (December 2000). "A specificity and targeting subunit of a human SWI/SNF family-related chromatin-remodeling complex". Molecular and Cellular Biology. 20 (23): 8879–8888. PMID 11073988.
- Takeuchi T, Nicole S, Misaki A, Furihata M, Iwata J, Sonobe H, et al. (February 2001). "Expression of SMARCF1, a truncated form of SWI1, in neuroblastoma". The American Journal of Pathology. 158 (2): 663–672. PMID 11159203.
- Kozmik Z, Machon O, Králová J, Kreslová J, Paces J, Vlcek C (April 2001). "Characterization of mammalian orthologues of the Drosophila osa gene: cDNA cloning, expression, chromosomal localization, and direct physical interaction with Brahma chromatin-remodeling complex". Genomics. 73 (2): 140–148. PMID 11318604.
- Kato H, Tjernberg A, Zhang W, Krutchinsky AN, An W, Takeuchi T, et al. (February 2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". The Journal of Biological Chemistry. 277 (7): 5498–5505. PMID 11734557.
- Lemon B, Inouye C, King DS, Tjian R (2002). "Selectivity of chromatin-remodelling cofactors for ligand-activated transcription". Nature. 414 (6866): 924–928. S2CID 4391100.
- Hurlstone AF, Olave IA, Barker N, van Noort M, Clevers H (May 2002). "Cloning and characterization of hELD/OSA1, a novel BRG1 interacting protein". The Biochemical Journal. 364 (Pt 1): 255–264. PMID 11988099.
- Inoue H, Furukawa T, Giannakopoulos S, Zhou S, King DS, Tanese N (November 2002). "Largest subunits of the human SWI/SNF chromatin-remodeling complex promote transcriptional activation by steroid hormone receptors". The Journal of Biological Chemistry. 277 (44): 41674–41685. PMID 12200431.
- Nie Z, Yan Z, Chen EH, Sechi S, Ling C, Zhou S, et al. (April 2003). "Novel SWI/SNF chromatin-remodeling complexes contain a mixed-lineage leukemia chromosomal translocation partner". Molecular and Cellular Biology. 23 (8): 2942–2952. PMID 12665591.
- Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, et al. (June 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–917. PMID 12837248.
External links
- ARID1A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human ARID1A genome location and ARID1A gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: O14497 (AT-rich interactive domain-containing protein 1A) at the PDBe-KB.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.