ARID2

Source: Wikipedia, the free encyclopedia.
ARID2
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_152641
NM_001347839

NM_175251

RefSeq (protein)

NP_001334768
NP_689854

NP_780460

Location (UCSC)Chr 12: 45.73 – 45.91 MbChr 15: 96.19 – 96.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

AT-rich interactive domain-containing protein 2 (ARID2) is a protein that in humans is encoded by the ARID2 gene.[5]

Function

ARID2 is a subunit of the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activation by nuclear receptors.[5]

Structure

The ARID2 protein contains two

N-terminal AT-rich DNA interaction domain—the last domain for which the protein is named.[6]

Clinical significance

Mutation studies have revealed ARID2 to be a significant

tumor suppressor in many cancer subtypes. ARID2 mutations are prevalent in hepatocellular carcinoma[7] and melanoma.[8][9] Mutations are present in a smaller but significant fraction in a wide range of other tumors.[10] ARID2 mutations are enriched in hepatitis C virus-associated hepatocellular carcinoma in the US and European patient populations compared with the overall mutation frequency.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000189079 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033237 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ARID2 AT rich interactive domain 2 (ARID, RFX-like)".
  6. ^
    PMID 22095441
    .
  7. .
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Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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