ARID2
ARID2 | |||
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Identifiers | |||
Gene ontology | |||
Molecular function | |||
Cellular component | |||
Biological process |
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Sources:Amigo / QuickGO |
Ensembl | |||||||||
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UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 12: 45.73 – 45.91 Mb | Chr 15: 96.19 – 96.3 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
AT-rich interactive domain-containing protein 2 (ARID2) is a protein that in humans is encoded by the ARID2 gene.[5]
Function
ARID2 is a subunit of the PBAF chromatin-remodeling complex, which facilitates ligand-dependent transcriptional activation by nuclear receptors.[5]
Structure
The ARID2 protein contains two
Clinical significance
Mutation studies have revealed ARID2 to be a significant
tumor suppressor in many cancer subtypes. ARID2 mutations are prevalent in hepatocellular carcinoma[7] and melanoma.[8][9] Mutations are present in a smaller but significant fraction in a wide range of other tumors.[10] ARID2 mutations are enriched in hepatitis C virus-associated hepatocellular carcinoma in the US and European patient populations compared with the overall mutation frequency.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000189079 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033237 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: ARID2 AT rich interactive domain 2 (ARID, RFX-like)".
- ^ PMID 22095441.
- PMID 21822264.
- PMID 22817889.
- PMID 22842228.
- PMID 23355908.
Further reading
- Martens JA, Winston F (Apr 2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes". Current Opinion in Genetics & Development. 13 (2): 136–42. PMID 12672490.
- Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (4): 273–81. PMID 10997877.
- Mohrmann L, Langenberg K, Krijgsveld J, Kal AJ, Heck AJ, Verrijzer CP (Apr 2004). "Differential targeting of two distinct SWI/SNF-related Drosophila chromatin-remodeling complexes". Molecular and Cellular Biology. 24 (8): 3077–88. PMID 15060132.
- Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. S2CID 27764390.
- Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C (Aug 2004). "Identification of interaction partners and substrates of the cyclin A1-CDK2 complex". The Journal of Biological Chemistry. 279 (32): 33727–41. PMID 15159402.
- Patsialou A, Wilsker D, Moran E (2005). "DNA-binding properties of ARID family proteins". Nucleic Acids Research. 33 (1): 66–80. PMID 15640446.
- Wilsker D, Probst L, Wain HM, Maltais L, Tucker PW, Moran E (Aug 2005). "Nomenclature of the ARID family of DNA-binding proteins". Genomics. 86 (2): 242–51. PMID 15922553.
- Yan Z, Cui K, Murray DM, Ling C, Xue Y, Gerstein A, Parsons R, Zhao K, Wang W (Jul 2005). "PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes". Genes & Development. 19 (14): 1662–7. PMID 15985610.
- Zhang X, Azhar G, Zhong Y, Wei JY (Aug 2006). "Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation". Biochemical and Biophysical Research Communications. 346 (3): 794–801. PMID 16782067.
External links
- ARID2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human ARID2 genome location and ARID2 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.