Source: Wikipedia, the free encyclopedia.
Protein-coding gene in the species Homo sapiens
ASAH2 Available structures Gene ontology
Molecular function Cellular component Biological process Sources:Amigo / QuickGO
Wikidata
Neutral ceramidase is an enzyme that in humans is encoded by the ASAH2 gene .[5] [6]
References
External links
Further reading
Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression". Gene . 146 (2): 199–207. .
Tani M, Okino N, Mori K, et al. (2000). "Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases" . J. Biol. Chem . 275 (15): 11229–34. .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. .
Choi MS, Anderson MA, Zhang Z, et al. (2004). "Neutral ceramidase gene: role in regulating ceramide-induced apoptosis". Gene . 315 : 113–22. .
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10" . Nature . 429 (6990): 375–81. .
Monick MM, Mallampalli RK, Bradford M, et al. (2004). "Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity" . J. Immunol . 173 (1): 123–35. .
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. .
Hwang YH, Tani M, Nakagawa T, et al. (2005). "Subcellular localization of human neutral ceramidase expressed in HEK293 cells". Biochem. Biophys. Res. Commun . 331 (1): 37–42. .
Osawa Y, Uchinami H, Bielawski J, et al. (2005). "Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha" . J. Biol. Chem . 280 (30): 27879–87. .
Tani M, Sano T, Ito M, Igarashi Y (2006). "Mechanisms of sphingosine and sphingosine 1-phosphate generation in human platelets" . J. Lipid Res . 46 (11): 2458–67. .
Galadari S, Wu BX, Mao C, et al. (2006). "Identification of a novel amidase motif in neutral ceramidase" . Biochem. J . 393 (Pt 3): 687–95. .
Xu R, Jin J, Hu W, et al. (2006). "Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P" . FASEB J . 20 (11): 1813–25. .
Avramopoulos D, Wang R, Valle D, et al. (2007). "A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease". Neurogenetics . 8 (2): 111–20. .
Ohlsson L, Palmberg C, Duan RD, et al. (2007). "Purification and characterization of human intestinal neutral ceramidase". Biochimie . 89 (8): 950–60. .