ATF1

Source: Wikipedia, the free encyclopedia.
ATF1
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_005171

XM_036162179

RefSeq (protein)

NP_005162

n/a

Location (UCSC)Chr 12: 50.76 – 50.82 MbChr X: 52.89 – 52.89 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclic AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene.

This gene encodes an activating

bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.[5]

Clinical significance

Fusion of this gene and

EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6.[5][6]

See also

Interactions

ATF1 has been shown to

interact
with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123268 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000080968 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: ATF1 activating transcription factor 1".
  6. S2CID 10944105
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  7. .
  8. ^ .
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Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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