Atrioventricular node
Atrioventricular node | |
---|---|
Electrical conduction system of the heart | |
Artery | Atrioventricular nodal branch |
Identifiers | |
Latin | nodus atrioventricularis |
Acronym(s) | AV node |
MeSH | D001283 |
TA98 | A12.1.06.004 |
TA2 | 3954 |
FMA | 9478 |
Anatomical terminology] |
The atrioventricular node or AV node electrically connects the
Structure
Location
The AV node lies at the lower back section of the interatrial septum near the opening of the coronary sinus, which conducts the normal electrical impulse from the atria to the ventricles. The AV node is quite compact (~1 x 3 x 5 mm).[2] It is located at the center of Koch's triangle—a triangle enclosed by the septal leaflet of the tricuspid valve, the coronary sinus, and the membranous part of the interatrial septum.[3]
Blood supply
The blood supply of the AV node is from the
Development
Bone morphogenetic protein (BMP) cell signaling plays a key role in diverse aspects of cardiac differentiation and morphogenesis. (BMPs) are multifunctional signaling molecules critical for the development of AV node. BMP influences AV node development through Alk3 receptor (Activin receptor-like kinase 3). Abnormalities seen in BMP and Alk3 are associated with some cardiovascular diseases like Ebstein’s anomaly and AV conduction disease.[7]
Function
The AV node receives two inputs from the right atrium: posteriorly, via the crista terminalis, and anteriorly, via the interatrial septum.[8]
Contraction of
This also protects the ventricles from excessively fast rate response to atrial
AV conduction during normal cardiac rhythm occurs through two different pathways:
- the first “pathway” has a slow conduction velocity but shorter refractory period
- the second “pathway” has a faster conduction velocity but longer refractory period.[11]
An important property that is unique to the AV node is decremental conduction,[12] in which the more frequently the node is stimulated the slower it conducts. This is the property of the AV node that prevents rapid conduction to the ventricle in cases of rapid atrial rhythms, such as atrial fibrillation or atrial flutter.
The AV node's normal intrinsic firing rate without stimulation (such as that from the SA node) is 40–60 times/minute.[13] This property is important because loss of the conduction system before the AV node should still result in pacing of the ventricles by the slower pacemaking ability of the AV node.
Clinical significance
- Atrioventricular conduction disease (AV block) describes impairment of the electrical continuity between the atria and ventricles. It occurs when the atrial depolarization fails to reach the ventricles or is conducted with an abnormally long delay. It can result from an injury or be a genetically inherited disorder.[14]
- Atrioventricular nodal re-entry tachycardia,[11] which is caused by a dual AV node physiology and AVNRT can only occur in people with it, however almost half of the population have it, though only a few of them will develop AVNRT at some point in life.[15]
- endodermal origin and occurs exclusively in the area of the AV node, tricuspid valve, and interatrial septum.[16]
See also
References
- ^ ISBN 978-0-86542-864-5.
- ^ a b Full Size Picture triangle of-Koch.jpg. Retrieved on 2008-12-22
- ^ Harrison's Principles of Internal Medicine, 17e” Section 3: Disorders of Rhythm Archived July 7, 2011, at the Wayback Machine
- PMID 5086972.
- PMID 18652764.
- PMID 18024438.
- PMID 17998461.
- PMID 11583910.
- ^ Campbell, N., & Reece, J. (2002). Biology. 6th ed. San Francisco: Benjamin Cummings[page needed][ISBN missing]
- ISBN 978-0-86542-864-5.
- ^ ISBN 978-0-86542-864-5.
- S2CID 22728910.
- ISBN 978-0-7216-0240-0.
- PMID 15372490.
- ^ "Dual Atrioventricular Nodal Physiology - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2022-11-14.
- PMID 19144541.
External links
- Anatomy figure: 20:06-02 at Human Anatomy Online, SUNY Downstate Medical Center – "The conduction system of the heart."
- thoraxlesson4 at The Anatomy Lesson by Wesley Norman (Georgetown University) (thoraxheartinternalner)
- https://web.archive.org/web/20070929080346/http://www.healthyheart.nhs.uk/heart_works/heart03.shtml