Abacavir/lamivudine/zidovudine

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Abacavir/lamivudine/zidovudine
reverse transcriptase inhibitor
Clinical data
Trade namesTrizivir
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa616051
License data
Pregnancy
category
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
NIAID ChemDB
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Abacavir/lamivudine/zidovudine, sold under the brand name Trizivir, is a

GlaxoSmithKline and marketed by a joint venture with Pfizer, ViiV Healthcare:[5]

It is indicated in the treatment of

mother-to-child transmission.[6]

The most common effects include headache and nausea (feeling sick).[3]

Abacavir/lamivudine/zidovudine was approved for use in the United States and the European Union in 2000.[7][3] In December 2013, Lupin Limited launched a generic version of abacavir/lamivudine/zidovudine.[8][9][10]

Side effects

The most common side effects of abacavir/lamivudine/zidovudine include nausea, vomiting, diarrhea, fatigue, paresthesia and headache. As with many medications targeting reverse transcriptase, body fat redistribution syndrome may occur, causing body fat to center on the upper back and neck, breast, and torso, and potentially decreasing around the legs, arms, and face.[11] IRIS may occur which is when the immune system initially improves, but then deteriorates as a previously ignored infection becomes active. Other serious side effects include:[12]

See also

References

  1. ^ "Abacavir / lamivudine / zidovudine (Trizivir) Use During Pregnancy". Drugs.com. 8 May 2018. Retrieved 7 April 2020.
  2. ^ a b c "Trizivir- abacavir sulfate, lamivudine, and zidovudine tablet, film coated". DailyMed. 10 May 2019. Retrieved 7 April 2020.
  3. ^ a b c d "Trizivir EPAR". European Medicines Agency (EMA). Retrieved 7 April 2020.
  4. PMID 12001042
    .
  5. ^ "GlaxoSmithKline-Pfizer launch HIV joint venture". InPharm.com. Archived from the original on 4 January 2012.
  6. PMID 19160297
    .
  7. ^ "Drug Approval Package: Trizivir (abacavir sulfate, lamivudine, zidovudine) NDA #021205". U.S. Food and Drug Administration (FDA). 28 March 2004. Retrieved 7 April 2020.
  8. ^ Monthly Prescribing Reference (MPR)
  9. ^ "Abacavir Sulfate". Lupin Pharma.
  10. ^ "Abacavir sulfate, lamivudine and zidovudine: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 6 July 2020.
  11. ^ ViiV Healthcare (March 2017). "Trizivir Medication Guide" (PDF). Archived (PDF) from the original on 22 December 2019.
  12. ^ "Side Effects of Trizivir (Abacavir Sulfate, Lamivudine, and Zidovudine), Warnings, Uses". RxList. Retrieved 22 December 2019.

External links