Abdominal pain

Abdominal pain, also known as a stomach ache, is a

Common causes of pain in the abdomen include gastroenteritis and irritable bowel syndrome.^[2] About 15% of people have a more serious underlying condition such as appendicitis, leaking or ruptured abdominal aortic aneurysm, diverticulitis, or ectopic pregnancy.^[2] In a third of cases, the exact cause is unclear.^[2]

Signs and symptoms

The onset of abdominal pain can be abrupt, quick, or gradual. Sudden onset pain happens in a split second. Rapidly onset pain starts mild and gets worse over the next few minutes. Pain that gradually intensifies only after several hours or even days has passed is referred to as gradual onset pain.^[4]

One can describe abdominal pain as either continuous or sporadic and as cramping, dull, or aching. The characteristic of cramping abdominal pain is that it comes in brief waves, builds to a peak, and then abruptly stops for a period during which there is no more pain. The pain flares up and off periodically. The most common cause of persistent dull or aching abdominal pain is edema or distention of the wall of a hollow viscus. A dull or aching pain may also be felt due to a stretch in the liver and spleen capsules.^[4]

Causes

The most frequent reasons for abdominal pain are

Acute abdomen is a condition where there is a sudden onset of severe abdominal pain requiring immediate recognition and management of the underlying cause.^[7] The underlying cause may involve infection, inflammation, vascular occlusion or bowel obstruction.^[7]

The pain may elicit

A more extensive list includes the following:^[citation needed]

• Gastrointestinal
  • GI tract
    • Inflammatory: gastroenteritis, appendicitis, gastritis, esophagitis, diverticulitis, Crohn's disease, ulcerative colitis, microscopic colitis
    • Obstruction:
      hemorrhoids
    • Vascular:
      hemorrhage, sickle cell disease, abdominal angina, blood vessel compression (such as celiac artery compression syndrome), superior mesenteric artery syndrome, postural orthostatic tachycardia syndrome
    • food allergies, indigestion
  • Glands
    • Bile system
      • Inflammatory:
        cholangitis
      • Obstruction:
        cholelithiasis
    • Liver
      • Inflammatory: hepatitis, liver abscess
    • Pancreatic
      • Inflammatory: pancreatitis
• Renal and urological
  • Inflammation:
    bladder infection
  • Obstruction:
    urolithiasis, urinary retention
  • Vascular:
    left renal vein entrapment
• Gynaecological or obstetric
  • Inflammatory: pelvic inflammatory disease
  • Mechanical: ovarian torsion
  • Endocrinological: menstruation, Mittelschmerz
  • Tumors: endometriosis, fibroids, ovarian cyst, ovarian cancer
  • Pregnancy: ruptured
    threatened abortion
• Abdominal wall
  • muscle strain or trauma
  • muscular infection
  • radiculitis in Lyme disease, abdominal cutaneous nerve entrapment syndrome (ACNES), tabes dorsalis
• Referred pain
  • from the
    ischemic heart disease, pericarditis
  • from the
    radiculitis
  • from the
    genitals: testicular torsion
• Metabolic disturbance
  • C1-esterase inhibitor deficiency, adrenal insufficiency, lead poisoning, black widow spider bite, narcotic withdrawal
• Blood vessels
  • aortic dissection, abdominal aortic aneurysm
• Immune system
  • sarcoidosis
  • vasculitis
  • familial Mediterranean fever
• Idiopathic
  • irritable bowel syndrome (IBS) (affecting up to 20% of the population, IBS is the most common cause of recurrent and intermittent abdominal pain)

By location

The location of abdominal pain can provide information about what may be causing the pain. The abdomen can be divided into four regions called quadrants. Locations and associated conditions include:^[12][13]

• Diffuse
  • Peritonitis
  • Vascular:
    systemic lupus erythematosus, polyarteritis nodosa
  • Small bowel obstruction
  • Irritable bowel syndrome
  • Metabolic disorders: ketoacidosis, porphyria, familial Mediterranean fever, adrenal crisis
• Epigastric
  • Heart: myocardial infarction, pericarditis
  • Stomach:
    stomach ulcer, stomach cancer
  • Pancreas: pancreatitis, pancreatic cancer
  • Intestinal: duodenal ulcer, diverticulitis, appendicitis
• Right upper quadrant
  • Liver:
    fatty liver, hepatitis, liver cancer, abscess
  • Gallbladder and biliary tract:
    cholangitis
  • Colon:
    colon cancer
  • Other: pneumonia, Fitz-Hugh-Curtis syndrome
• Left upper quadrant
  • Splenomegaly
  • Colon: bowel obstruction, functional disorders, gas accumulation, spasm, inflammation, colon cancer
• Peri-umbilical (the area around the umbilicus, aka the belly button)
  • Appendicitis
  • Pancreatitis
  • Inferior myocardial infarction
  • Peptic ulcer
  • Diabetic ketoacidosis
  • Vascular: aortic dissection, aortic rupture
  • Bowel:
    mesenteric ischemia, Celiac disease, inflammation, intestinal spasm, functional disorders, small bowel obstruction
• Lower abdominal pain
  • Diarrhea
  • Colitis
  • Crohn's
  • Dysentery
  • Hernia
• Right lower quadrant
  • Colon: intussusception, bowel obstruction, appendicitis (McBurney's point)
  • Renal: kidney stone (nephrolithiasis), pyelonephritis
  • Pelvic:
    cystitis, bladder stone, bladder cancer, pelvic inflammatory disease
    , pelvic pain syndrome
  • Gynecologic: endometriosis, intrauterine pregnancy, ectopic pregnancy, ovarian cyst, ovarian torsion, fibroid (leiomyoma), abscess, ovarian cancer, endometrial cancer
• Left lower quadrant
  • Bowel: diverticulitis, sigmoid colon volvulus, bowel obstruction, gas accumulation, Toxic megacolon
• Right low back pain
  • Liver: hepatomegaly
  • Kidney: kidney stone (nephrolithiasis), complicated urinary tract infection
• Left low back pain
  • Spleen
  • Kidney: kidney stone (nephrolithiasis), complicated urinary tract infection
• Low back pain
  • Kidney pain (
    kidney stone, kidney cancer, hydronephrosis
    )
  • Ureteral stone pain

Mechanism

Abdominal pain can be referred to as visceral pain or peritoneal pain. The contents of the abdomen can be divided into the foregut, midgut, and hindgut.^[14] The foregut contains the pharynx, lower respiratory tract, portions of the esophagus, stomach, portions of the duodenum (proximal), liver, biliary tract (including the gallbladder and bile ducts), and the pancreas.^[14] The midgut contains portions of the duodenum (distal), cecum, appendix, ascending colon, and first half of the transverse colon.^[14] The hindgut contains the distal half of the transverse colon, descending colon, sigmoid colon, rectum, and superior anal canal.^[14]

Each subsection of the gut has an associated visceral afferent nerve that transmits sensory information from the viscera to the spinal cord, traveling with the autonomic sympathetic nerves.^[16] The visceral sensory information from the gut traveling to the spinal cord, termed the visceral afferent, is non-specific and overlaps with the somatic afferent nerves, which are very specific.^[17] Therefore, visceral afferent information traveling to the spinal cord can present in the distribution of the somatic afferent nerve; this is why appendicitis initially presents with T10 periumbilical pain when it first begins and becomes T12 pain as the abdominal wall peritoneum (which is rich with somatic afferent nerves) is involved.^[17]

Diagnosis

A thorough patient history and physical examination is used to better understand the underlying cause of abdominal pain.

The process of gathering a history may include:^[18]

• Identifying more information about the
  chief complaint by eliciting a history of present illness; i.e. a narrative of the current symptoms such as the onset, location, duration, character, aggravating or relieving factors, and temporal nature of the pain. Identifying other possible factors may aid in the diagnosis of the underlying cause of abdominal pain, such as recent travel, recent contact with other ill individuals, and for females, a thorough gynecologic
  history.
• Learning about the patient's past medical history, focusing on any prior issues or surgical procedures.
• Clarifying the patient's current medication regimen, including prescriptions, over-the-counter medications, and supplements.
• Confirming the patient's drug and food allergies.
• Discussing with the patient any family history of disease processes, focusing on conditions that might resemble the patient's current presentation.
• Discussing with the patient any health-related behaviors (e.g. tobacco use, alcohol consumption, drug use, and sexual activity) that might make certain diagnoses more likely.
• Reviewing the presence of non-abdominal symptoms (e.g., fever, chills, chest pain, shortness of breath, vaginal bleeding) that can further clarify the diagnostic picture.
• Using Carnett's sign to differentiate between visceral pain and pain originating in the muscles of the abdominal wall.^[19]

After gathering a thorough history, one should perform a physical exam in order to identify important physical signs that might clarify the diagnosis, including a cardiovascular exam, lung exam, thorough abdominal exam, and for females, a genitourinary exam.^[18]

Additional investigations that can aid diagnosis include:^[20]

• Blood tests including complete blood count, basic metabolic panel, electrolytes, liver function tests, amylase, lipase, troponin I, and for females, a serum pregnancy test.
• Urinalysis
• Imaging including chest and abdominal X-rays
• Electrocardiogram

If diagnosis remains unclear after history, examination, and basic investigations as above, then more advanced investigations may reveal a diagnosis. Such tests include:^[20]

• Computed tomography
  of the abdomen/pelvis
• Abdominal or pelvic ultrasound
• Endoscopy or colonoscopy

Management

The management of abdominal pain depends on many factors, including the etiology of the pain. Some dietary changes that some may participate in are: resting after a meal, chewing food completely and slowly, and avoiding stressful and high excitement situations after a meal. Some at home strategies like these can avoid future abdominal issues, resulting in the need of professional assistance.

Abdominal pain is the reason about 3% of adults see their family physician.[2] Rates of emergency department (ED) visits in the United States for abdominal pain increased 18% from 2006 through to 2011. This was the largest increase out of 20 common conditions seen in the ED. The rate of ED use for nausea and vomiting also increased 18%.^[28]

Special populations

Geriatrics

More time and resources are used on older patients with abdominal pain than on any other patient presentation in the emergency department (ED).^[29] Compared to younger patients with the same complaint, their length of stay is 20% longer, they need to be admitted almost half the time, and they need surgery 1/3 of the time.^[30]

Age does not reduce the total number of T cells, but it does reduce their functionality. The elderly person's ability to fight infection is weakened as a result.^[31] Additionally, they have changed the strength and integrity of their skin and mucous membranes, which are physical barriers to infection. It is well known that older patients experience altered pain perception.^[32]

The challenge of obtaining a sufficient history from an elderly patient can be attributed to multiple factors. Reduced memory or hearing could make the issue worse. It is common to encounter stoicism combined with a fear of losing one's independence if a serious condition is discovered. Changes in mental status, whether acute or chronic, are common.^[33]

Pregnancy

Unique clinical challenges arise when pregnant women experience abdominal pain. First off, there are many possible causes of abdominal pain during pregnancy. These include intraabdominal diseases that arise incidentally during pregnancy as well as obstetric or gynecologic disorders associated with pregnancy. Secondly, pregnancy modifies the natural history and clinical manifestation of numerous abdominal disorders. Third, pregnancy modifies and limits the diagnostic assessment. For instance, concerns about fetal safety during pregnancy are raised by invasive exams and radiologic testing. Fourth, while receiving therapy during pregnancy, the mother's and the fetus' interests need to be taken into account.^[34]

See also

• Abdominal distension
• Abdominal mass

References