Absolute neutrophil count
Absolute neutrophil count (ANC) is a measure of the number of
The ANC is almost always a part of a larger
Clinical significance
The reference range for ANC in adults varies by study, but 1500 to 8000 cells per microliter is typical. An ANC less than 1500 cells/μL is defined as neutropenia and increases risk of infection. Neutropenia is the condition of a low ANC, and the most common condition where an ANC would be measured is in the setting of chemotherapy for cancer.[citation needed]
Neutrophilia indicates an elevated count. While many clinicians refer to the presence of neutrophilia as a "left shift", this is imprecise, as a left shift indicates the presence of immature neutrophil forms,[citation needed] but neutrophilia refers to the entire mass of neutrophils, both mature and immature. Neutrophilia can be indicative of:
- Premature release of myeloid cells from the bone marrow.
- A leukemoid reaction.
Calculation
ANC =
or
ANC = (Absolute-Polys + Absolute-Bands)
Ranges
Neutropenia Risk Category | ANC |
---|---|
Mild | ≥ 1000 to < 1500 cells/μL |
Moderate | ≥ 500 to < 1000 cells/μL |
Severe | < 500 cells/μL |
Related tests
In some cases, a ratio is reported in addition to the sum. This is known as the "I/T ratio".[3][4]