Acetohexamide
Source: Wikipedia, the free encyclopedia.
Chemical compound
Not to be confused with acetazolamide.
Clinical data | |
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Trade names | Dymelor |
AHFS/Drugs.com | Micromedex Detailed Consumer Information |
MedlinePlus | a602021 |
ATC code | |
Pharmacokinetic data | |
Protein binding | 90% |
Identifiers | |
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JSmol) | |
Melting point | 188 to 190 °C (370 to 374 °F) |
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Acetohexamide (trade name Dymelor) is a first-generation
diabetes mellitus type 2, particularly in people whose diabetes cannot be controlled by diet alone.[1]
Mechanism of action
Acetohexamide bind to an
pancreatic beta cells. This inhibits the out flux of potassium, which causes the membrane potential to become more positive. This depolarization in turn opens voltage-gated calcium channels. The rise in intracellular calcium leads to increased fusion of insulin granulae with the cell membrane, and therefore increased secretion of insulin.[2]
Risks
Oral hypoglycemic drugs, including acetohexamide, have been associated with increased
cardiovascular mortality. Qualified healthcare professionals should consulted for possible risks, benefits, and alternatives of using this drug for treatment of type 2 diabetes.[3]
References
- PMID 14216839.
- ^ "Acetohexamide". DrugBank.
- ^ "Acetohexamide". Medline Plus. Archived from the original on 11 September 2005.
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VGKCsTooltip Voltage-gated potassium channels
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IRKsTooltip Inwardly rectifying potassium channel
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K2PsTooltip Tandem pore domain potassium channel
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VGSCsTooltip Voltage-gated sodium channels
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CaCCsTooltip Calcium-activated chloride channel
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TRPs Tooltip Transient receptor potential channels |
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LGICs Tooltip Ligand gated ion channels |
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