Acute infectious thyroiditis
Acute infectious thyroiditis | |
---|---|
Other names | suppurative thyroiditis |
Specialty | Endocrinology |
Acute infectious thyroiditis (AIT) also known as suppurative thyroiditis, microbial inflammatory thyroiditis, pyrogenic thyroiditis and bacterial thyroiditis.[1][2][3]
The
Signs and symptoms
In most cases AIT is characterized by onset of pain, firmness, tenderness, redness or swelling in the anterior aspect of the neck.
Causes
Despite the thyroid gland being extremely resistant to infection, it is still susceptible to infection by various bacteria. Occurrences of AIT are most common in patients with prior thyroid disease such as Hashimoto's thyroiditis or thyroid cancer. The most common cause of infection in children is a congenital abnormality such as pyriform sinus fistula.[5] In most cases, the infection originates in the piriform sinus and spreads to the thyroid via the fistula.[8] In many reported cases of AIT the infection occurs following an upper respiratory tract infection. One study found that of the reported cases of AIT, 66% occurred after an acute illness involving the upper respiratory tract.[6] Although the rates of infection are still very low, cases of AIT have been on the rise in recent years due to the higher occurrence of immune-compromised patients.[citation needed] Other causes of AIT are commonly due to contamination from an outside source and are included below.
Diagnosis
Patients who are suspected of having AIT often undergo tests to detect for elevated levels of
Diagnostic tests
- Fever, redness, swelling
- Pain
- Blood tests of thyroid functions including TSH, T4 and T3 are usually normal [3]
- Ultrasonographic examination often shows the abscess or swelling in thyroid
- Gallium scan will be positive
- Barium swallowwill show fistula connection to the piriform sinus and left lobe
- Elevated white blood cell count[3]
- Elevated erythrocyte sedimentation rate[3]
- Fine-needle aspiration
Subtypes of thyroiditis
Subtypes | Causes |
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Hashimoto's thyroiditis, Chronic lymphocytic thyroiditis,[3] Chronic autoimmune thyroiditis, Lymphadenoid goiter[5] | Autoimmune[3] |
Subacute lymphocytic thyroiditis, Postpartum thyroiditis, Sporadic painless thyroiditis,[3] Silent sporadic thyroiditis[5] | Autoimmune[3] |
Acute infectious thyroiditis, Microbial inflammatory thyroiditis, Suppurative thyroiditis,[3] Pyrogenic thyroiditis, Bacterial thyroiditis[5] | Cause: Bacterial, Parasitic, Fungal[3] |
de Quervain's thyroiditis, Subacute granulomatous thyroiditis,[3] Giant-cell thyroiditis, Pseudogranulomatous thyroiditis, Painful subacute thyroiditis,[5] | Viral[3] |
Riedel's thyroiditis, Riedel's struma, Invasive fibrous thyroiditis | Unknown[3] |
Treatment
Treatment of AIT involves antibiotic treatment. Based on the offending organism found on microscopic examination of the stained fine needle aspirate, the appropriate antibiotic treatment is determined. In the case of a severe infection,
Epidemiology
Acute infectious thyroiditis is very rare, with it only accounting for about 0.1–0.7% of all thyroiditis. Large hospitals tend to only see two cases of AIT annually.[2] For the few cases of AIT that are seen the statistics seem to show a pattern. AIT is found in children and young adults between the ages of 20 and 40. The occurrence of the disease in people between 20 and 40 is only about 8% with the other 92% being in children. Men and women are each just as likely to get the disease.[5] If left untreated, there is a 12% mortality rate.[2]
References
- ^ a b c d e Melmed, Shlomo, Kenneth S. Polonsky, and P. R. Larsen. thyroiditis vs subacute thyroiditis diagnosis criteria[permanent dead link] "Acute InfectiousThyroiditis." Willams Textbook of Endocrinology. By Henry M. Kronenberg. 11th ed. Philadelphia: Elsevier, 2008. 945-47.
- ^ a b c d e f Lazarus, John, and James Hennessey. "Acute and Subacute, and Reidel's thyroiditis – Thyroid Disease Manager". Archived from the original on 2012-04-29. Retrieved 2012-04-20. "Acute and Subacute, and Reidel’s Thyroiditis." Ed. Leslie J. De Groot. The Thyroid And Its Diseases. 6th ed. New York: Elsevier, 1996.
- ^ PMID 10706157. Retrieved 24 August 2012.
- ^ a b c d e f g h i j k l m n Brook, I. (2002). "Microbiology and management of acute suppurative thyroiditis in children." International Journal of Pediatric Otorhinolaryngology, 67, 447-451.
- ^ a b c d e f g h Pearce, Elizabeth M.D., Alan P. Farwell M.D. and Lewis E. Braverman M.D. "Thyroiditis." The New England Journal of Medicine. 2003 June 26;348:2646-2655.
- ^ a b c d Park, Sun W., Moon H. Han, Myung H. Sung, In O. Kim, Kwang H. Kim, Kee H. Chang, and Man C. Han. "Neck Infection Associated with Pyriform Sinus Fistula: Imaging Findings." American Journal of Neuroradiology Am J Neuroradiol 21 (2000): 817-22.
- ^ 3) Lazarus, John, and James Hennessey. "Acute and Subacute, and Reidel’s Thyroiditis." Ed. Leslie J. De Groot. The Thyroid And Its Diseases. 6th ed. New York: Elsevier, 1996
- ^ Yamada, H., Fujita, K., Tokuriki, T., & Ishida, R. (2002). "Nine cases of piriform sinus fistula with acute suppurative thyroiditis." Elsevier, 29, 361-365.