Acute tubular necrosis
Acute tubular necrosis | |
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Specialty | Nephrology |
Acute tubular necrosis (ATN) is a medical condition involving the
Classification
ATN may be classified as either
Diagnosis
Acute tubular necrosis is classified as a "renal" (i.e. not pre-renal or post-renal) cause of acute kidney injury. Diagnosis is made by a FENa (
Toxic ATN
Toxic ATN can be caused by free
Histopathology: Toxic ATN is characterized by proximal tubular epithelium necrosis (no nuclei, intense eosinophilic homogeneous cytoplasm, but preserved shape) due to a toxic substance (poisons, organic solvents, drugs, heavy metals). Necrotic cells fall into the tubule lumen, obturating it, and determining acute kidney failure. Basement membrane is intact,[citation needed] so the tubular epithelium regeneration is possible. Glomeruli are not affected.[2]
Ischemic ATN
Ischemic ATN can be caused when the
See also
- Acute interstitial nephritis
- Renal cortical necrosis
- Renal papillary necrosis
References
- ^ Desanti De Oliveira, B., Xu, K., Shen, T.H. et al. Molecular nephrology: types of acute tubular injury. Nat Rev Nephrol 15, 599–612 (2019). https://doi.org/10.1038/s41581-019-0184-x
- ^ a b c d "Acute Tubular Necrosis (ATN)". Nephrology Channel. HealthCommunities.com. 2008. Retrieved 2008-09-23.
- ^ OCLC 191854838.
- OCLC 191854838.[page needed]
- ^ TheFreeDictionary > tubulorrhexis Citing: The American Heritage Medical Dictionary 2007
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