Adenosylhomocysteinase

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S-Adenosylhomocysteine hydrolase
Chr. 20 q11.22
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Adenosylhomocysteinase (

S-adenosylhomocysteine to homocysteine and adenosine.[1][2] This enzyme catalyses the following chemical reaction

The enzyme contains one tightly bound NAD+ per subunit. The mechanism involves dehydrogenative oxidation of the 3'-OH of the ribose. The resulting ketone is susceptible to α-deprotonation. The resulting carbanion eliminates thiolate. The

a,b-unsaturated ketone
is then hydrated, and the ketone is reduced by the NADH.

This enzyme is encoded by the AHCY gene in humans,[3][4] which is believed to have a prognostic role in neuroblastoma.[5]

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