Adenosylhomocysteinase
S-Adenosylhomocysteine hydrolase | |||||||
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Chr. 20 q11.22 | |||||||
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Adenosylhomocysteinase (
S-adenosylhomocysteine to homocysteine and adenosine.[1][2] This enzyme catalyses the following chemical reaction
- S-adenosyl-L-homocysteine + H2O ⇌ L-homocysteine + adenosine
The enzyme contains one tightly bound NAD+ per subunit. The mechanism involves dehydrogenative oxidation of the 3'-OH of the ribose. The resulting ketone is susceptible to α-deprotonation. The resulting carbanion eliminates thiolate. The
a,b-unsaturated ketone
is then hydrated, and the ketone is reduced by the NADH.
This enzyme is encoded by the AHCY gene in humans,[3][4] which is believed to have a prognostic role in neuroblastoma.[5]
References
External links
- Adenosylhomocysteinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Further reading
- Vizán, Pedro; Di Croce, Luciano; Aranda, Sergi (31 March 2021). "Functional and Pathological Roles of AHCY". Frontiers in Cell and Developmental Biology. 9. PMID 33869213.
- Vugrek, Oliver; Belužić, Robert; Nakić, Nikolina; Mudd, S. Harvey (28 January 2009). "S-adenosylhomocysteine hydrolase (AHCY) deficiency: Two novel mutations with lethal outcome". Human Mutation. 30 (4): E555–E565. PMID 19177456.
- Chicco, Davide; Sanavia, Tiziana; Jurman, Giuseppe (4 March 2023). "Signature literature review reveals AHCY, DPYSL3, and NME1 as the most recurrent prognostic genes for neuroblastoma". BioData Mining. 16 (1): 7. PMID 36870971.