Adenovirus infection
Adenovirus infection | |
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Infectious diseases[1] | |
Symptoms |
|
Complications |
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Causes | Washing hands, social distancing, avoid touching eyes, nose and mouth[9] |
Treatment | Symptomatic and supportive[9] |
Prognosis | Usually recover without treatment[9] |
Frequency | Common, all ages,[3] typically children under 5-years[5] |
Adenovirus infection is a contagious
Adenovirus infection in humans are generally caused by
Diagnosis is by signs and symptoms, and a laboratory test is not usually required.
Adenovirus infections affect all ages.[3] They occur sporadically throughout the year, and outbreaks can occur particularly in winter and spring, when they may spread more quickly in closed populations such as in hospitals, nurseries, long-term care facilities, schools, and swimming pools.[11] Severe disease is rare in people who are otherwise healthy.[11] Adenovirus infection accounts for up to 10% of respiratory infections in children.[11] Most cases are mild and by the age of 10-years, most children have had at least one adenovirus infection.[5] 75% of conjunctivitis cases are due to adenovirus infection.[14] In 2016, the Global Burden of Disease Study estimated that globally, around 75 million episodes of diarrhea among children under the age of five-years, were attributable to adenovirus infection.[13] The first adenoviral strains were isolated in 1953 by Rowe et al.[15]
Signs and symptoms
Symptoms are variable, ranging from mild symptoms to severe illness.[5] They depend on the type of adenovirus, where it enters into the body, and on the age and well-being of the person.[2] Recognised patterns of clinical features include respiratory, eye, gastrointestinal, genitourinary and central nervous system.[2] There is also a widespread type that occurs in immunocompromised people.[2] Typical symptoms are of a mild cold or resembling the flu; fever, nasal congestion, coryza, cough, and pinky-red eyes.[6] Infants may also have symptoms of an ear infection.[2] Onset is usually two to fourteen days after exposure to the virus.[11] There may be tiredness, chills, muscle aches, or headache.[2] However, some people have no symptoms.[4] Generally, a day or two after developing a sore throat with large tonsils, glands can be felt in the neck.[16] Illness is more likely to be severe in people with weakened immune systems, particularly children who have had a hematopoietic stem cell transplantation.[8] Sometimes there is a skin rash.[5]
Respiratory tract
Preschool children with adenovirus colds tend to present with a
Eyes
Adenovirus eye infection may present as a pinkish-red eye.[5] Six to nine days following exposure to adenovirus, one or both eyes, typically in children, may be affected in association with fever, pharyngitis and lymphadenopathy (pharyngoconjunctival fever (PCF)).[2] The onset is usually sudden, and there is often rhinitis.[5] Adenovirus infection can also cause adenoviral keratoconjunctivitis.[5] Typically one eye is affected after an incubation period of up to a week.[5] The eye becomes itchy, painful, burning and reddish and lymphadenopathy may be felt by the ear nearest the affected eye.[5] The symptoms may last around 10 days to three weeks.[5] It may be is associated with blurred vision, photophobia and swelling of the conjunctiva.[5][14] A sore throat and nasal congestion may or may not be present.[5] This tends to occur in epidemics, affecting predominantly adults.[5] In very young children, it may be associated with high fever, sore throat, otitis media, diarrhoea, and vomiting.[5]
Gastrointestinal tract
Adenovirus infection can cause a
Other organs
Uncommonly the bladder may be affected, presenting with a sudden onset of
Cause and mechanism
Adenovirus infection in humans are generally caused by
Although
Several adenoviruses, including Ad5, Ad9, Ad31, Ad36, Ad37, and SMAM1, have at least some evidence of causation of
Diagnosis
Diagnosis is by signs and symptoms, and a laboratory test is not usually required.
Prevention
Infection by adenovirus may be prevented by
Treatment
Treatment is generally
Prognosis
After recovery from adenovirus infection, the virus can be carried for weeks or months.[11]
Adenovirus can cause severe necrotizing
Epidemiology
Adenovirus infections occur sporadically throughout the year, and outbreaks can occur particularly in winter and spring.[11] Epidemics may spread more quickly in closed populations such as in hospitals, nurseries, long-term care facilities, boarding schools, orphanages and swimming pools.[11] Severe disease is rare in people who are usually healthy.[11] Around 10% of respiratory infections in children are caused by adenoviruses.[11] Most are mild and by the age of 10-years, most children have had at least one adenovirus infection.[5]
Adenoviruses are the most common viruses causing an
Research in adenovirus infection has generally been limited relative to other respiratory disease viruses.[13] The impact of type-40/41 adenovirus diarrhoea is possibly underestimated.[13]
History
The first adenoviral strains were isolated from
The illness made headlines in Texas in September 2007, when a so-called "boot camp flu" sickened hundreds at Lackland Air Force Base in San Antonio.[22] In 2018, outbreaks occurred in an adult nursing home in New Jersey, and a college campus in Maryland.[3] In 2020, as a result of infection control measures during the COVID-19 pandemic, rates of adenovirus diarrhoea declined significantly in China.[23]
Other animals
Dogs can be affected by adenovirus infection.[24] Severe liver damage is a classical infectious disease seen in unvaccinated dogs.[25]
References
- ^ a b "Adenovirus Clinical Overview for Healthcare Professionals | CDC". www.cdc.gov. 29 November 2021. Retrieved 5 May 2022.
- ^ ISBN 978-0-323-55087-1.
- ^ a b c d e "Adenovirus Infection and Outbreaks: What You Need to Know" (PDF). Am J Respir Crit Care Med. 199. American Thoracic Society: 13–14. 2019. Retrieved 7 May 2022.
- ^ a b c d e f g h Tesini, Brenda L. (April 2022). "Adenovirus Infections - Infectious Diseases". MSD Manual Professional Edition. Retrieved 7 May 2022.
- ^ S2CID 237479412.
- ^ a b c "Adenovirus: symptoms". www.cdc.gov. 16 March 2021. Archived from the original on 18 April 2020. Retrieved 23 April 2022.
- ^ a b c d "Adenovirus: transmission". www.cdc.gov. 29 November 2021. Retrieved 7 May 2022.
- ^ S2CID 240127201.
- ^ a b c d e f g h i j k l m n "Adenovirus: preventing and treating Adenovirus". www.cdc.gov. 29 November 2021. Retrieved 7 May 2022.
- ^ a b "Adenovirus". www.cdc.gov. 16 March 2021. Retrieved 23 April 2022.
- ^ PMID 27486739.
- ^ ISBN 978-981-310-979-7.
- ^ PMID 32773498.
- ^ PMID 32256043.
- ^ ISBN 0-8493-3646-5.
- ^ ISBN 978-0-7020-7870-5.
- PMID 30725967.
- ^ a b This article incorporates public domain material from Respiratory and Enteric Viruses Branch. Centers for Disease Control and Prevention. Archived from the original on July 3, 2007. Retrieved 2007-07-03.
- S2CID 5370331.
- ^ "Clinical Diagnosis of Adenovirus". www.cdc.gov. 29 November 2021. Retrieved 7 May 2022.
- ^ ISBN 978-0-8089-2325-1.
- ^ New York Times Archived 2015-06-11 at the Wayback Machine article New Form of Virus Has Caused 10 Deaths in 18 Months published November 16, 2007
- PMID 35474224.
- ISBN 978-1-119-02893-2.
- S2CID 228935463.