Adherens junction
| Adherens junction | |
|---|---|
| Details | |
| Identifiers | |
| Latin | junctio adhaesionis |
| MeSH | D022005 |
| TH | H1.00.01.1.02002 |
| FMA | 67400 |
| Anatomical terminology | |
In
cytoplasmic face is linked to the actin cytoskeleton
.
They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (focal adhesion).
Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells.[3]
A similar cell junction in non-epithelial, non-endothelial cells is the
cardiomyocytes
.
Proteins
Adherens junctions are composed of the following proteins:[4]
- cadherins. The cadherins are a family of transmembrane proteins that form homodimers in a calcium-dependent manner with other cadherin molecules on adjacent cells.
- p120 (sometimes called delta catenin) binds the juxtamembrane region of the cadherin.
- γ-catenin or gamma-catenin (plakoglobin) binds the catenin-binding region of the cadherin.
- β-catenin or plakoglobin and links the actin cytoskeleton with cadherin. Significant protein dynamics are thought to be involved.[5]
Models
Adherens junctions were, for many years, thought to share the characteristic of anchor cells through their cytoplasmic actin filaments.[citation needed]
Adherens junctions may serve as a regulatory module to maintain the actin
contractile ring with which it is associated in microscopic studies.[citation needed
]
See also
References
- PMID 370125. Retrieved 15 October 2014.)
{{cite journal}}: CS1 maint: multiple names: authors list (link - S2CID 11590025.
- PMID 26738975.
- ISBN 978-3-527-31882-7.
- PMID 33753508.
External links
Wikimedia Commons has media related to Adherens junctions.
- MBInfo - Adherens Junction
- MBInfo - Adherens Junction Assembly
- Adherens+Junctions at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Histology image: 20502loa – Histology Learning System at Boston University