Adolfo García-Sastre
Adolfo García-Sastre | |
---|---|
Born | Mount Sinai Medical Center | 10 October 1964
Adolfo García-Sastre,(born in Burgos, 10 October 1964) is a Spanish professor of Medicine and Microbiology and co-director of the Global Health & Emerging Pathogens Institute at the Icahn School of Medicine at Mount Sinai in New York City. His research into the biology of influenza viruses has been at the forefront of medical advances in epidemiology.[1]
García-Sastre is the author of more than 200 publications.
Biography
Born in
In 2005, as principal investigator of an
García-Sastre is an editor for the Journal of Experimental Medicine and PLOS Pathogens, and he sits on the editorial boards of the Journal of Virology, Virology, Virus Research and the Journal of General Virology. In 2001, he co-organized the International Course on Viral Vectors in Heidelberg, Germany, which was sponsored by the Federation of European Biochemical Societies (FEBS), as well as the first Research Conference on Orthomyxoviruses, also in 2001, which was held in the Netherlands and sponsored by the European Scientific Working Group on Influenza.[2] He is a co-founder of Vivaldi Biosciences and a member of the company's Scientific Advisory board[3] and is the leader of the basic research component on the NIAID-funded Viral Therapeutics and Pathogenesis of the North East Biodefense Center proposal.[4] He was among the first members of the Vaccine Study Section of the National Institutes of Health.[5] He is also principal investigator for the Center for Research on Influenza Pathogenesis, one of five NIAID Centers of Excellence for Influenza Research and Surveillance (CEIRS).
He was elected to the National Academy of Sciences in 2019.[6]
Patents
García-Sastre holds 7 patents:[7]
Number | Title |
---|---|
20090280144 | Recombinant newcastle disease virus RNA expression systems and vaccines[8] |
20090203114 | Novel methods and Interferon deficient substrates for the propagation of virues[9] |
20090061521 | Recombinant negative strand RNA virus expression systems and vaccines[10] |
20090053264 | Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals[11] |
20090028901 | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents[12] |
20090010962 | Genetically Engineered Swine Influenza Virus and Uses Thereof[13] |
20080254060 | Genetically Engineered Equine Influenza Virus and Uses Thereof[14] |
Publications
Partial List:
- Mueller, S. N.; Langley, W. A.; Carnero, E.; Garcia-Sastre, A.; Ahmed, R. (2009). "Immunization with Live Attenuated Influenza Viruses That Express Altered NS1 Proteins Results in Potent and Protective Memory CD8+ T-Cell Responses". Journal of Virology. 84 (4): 1847–1855. PMID 19939929.
- Martinez-Sobrido, L.; Cadagan, R.; Steel, J.; Basler, C. F.; Palese, P.; Moran, T. M.; Garcia-Sastre, A. (2009). "Hemagglutinin-Pseudotyped Green Fluorescent Protein-Expressing Influenza Viruses for the Detection of Influenza Virus Neutralizing Antibodies". Journal of Virology. 84 (4): 2157–2163. PMID 19939917.
- Nistal-Villán, E.; García-Sastre, A. (2009). "Attacking the flu: New prospects for the rational design of antivirals". Nature Medicine. 15 (11): 1253–1254. PMID 19893557.
- Babiuk, S.; Albrecht, R.; Berhane, Y.; Marszal, P.; Richt, J. A.; Garcia-Sastre, A.; Pasick, J.; Weingartl, H. (2009). "1918 and 2009 H1N1 influenza viruses are not pathogenic in birds". Journal of General Virology. 91 (2): 339–342. PMID 19889930.
- Baum, A.; García-Sastre, A. (2009). "Induction of type I interferon by RNA viruses: Cellular receptors and their substrates". Amino Acids. 38 (5): 1283–1299. PMID 19882216.
- Tscherne, D. M.; Manicassamy, B.; García-Sastre, A. (2010). "An enzymatic virus-like particle assay for sensitive detection of virus entry". Journal of Virological Methods. 163 (2): 336–343. PMID 19879300.
- Gannagé, M.; Dormann, D.; Albrecht, R.; Dengjel, J. R.; Torossi, T.; Rämer, P. C.; Lee, M.; Strowig, T.; Arrey, F.; Conenello, G.; Pypaert, M.; Andersen, J.; García-Sastre, A.; Münz, C. (2009). "Matrix Protein 2 of Influenza a Virus Blocks Autophagosome Fusion with Lysosomes". Cell Host & Microbe. 6 (4): 367–380. PMID 19837376.
- Steel, J.; Staeheli, P.; PMID 19828604.
- Richt, J. E. A.; García-Sastre, A. (2009). "Attenuated Influenza Virus Vaccines with Modified NS1 Proteins". Vaccines for Pandemic Influenza. Current Topics in Microbiology and Immunology. Vol. 333. pp. 177–195. PMID 19768406.
- Kochs, G.; Martinez-Sobrido, L.; Lienenklaus, S.; Weiss, S.; Garcia-Sastre, A.; Staeheli, P. (2009). "Strong interferon-inducing capacity of a highly virulent variant of influenza a virus strain PR8 with deletions in the NS1 gene". Journal of General Virology. 90 (12): 2990–2994. PMID 19726611.
- Guo, H.; Kumar, P.; Moran, T. M.; Garcia-Sastre, A.; Zhou, Y.; Malarkannan, S. (2009). "The functional impairment of natural killer cells during influenza virus infection". Immunology and Cell Biology. 87 (8): 579–589. PMID 19721456.
- Martinez-Sobrido, L.; Emonet, S.; Giannakas, P.; Cubitt, B.; Garcia-Sastre, A.; De La Torre, J. C. (2009). "Identification of Amino Acid Residues Critical for the Anti-Interferon Activity of the Nucleoprotein of the Prototypic Arenavirus Lymphocytic Choriomeningitis Virus". Journal of Virology. 83 (21): 11330–11340. PMID 19710144.
- Billharz, R.; Zeng, H.; Proll, S. C.; Korth, M. J.; Lederer, S.; Albrecht, R.; Goodman, A. G.; Rosenzweig, E.; Tumpey, T. M.; García-Sastre, A.; Katze, M. G. (2009). "The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways". Journal of Virology. 83 (20): 10557–10570. PMID 19706713.
- Bolland, S.; Garcia-Sastre, A. (2009). "Vicious circle: Systemic autoreactivity in Ro52/TRIM21-deficient mice". Journal of Experimental Medicine. 206 (8): 1647–1651. PMID 19635865.
- Kuri, T.; Zhang, X.; Habjan, M.; Martinez-Sobrido, L.; Garcia-Sastre, A.; Yuan, Z.; Weber, F. (2009). "Interferon priming enables cells to partially overturn the SARS coronavirus-induced block in innate immune activation". Journal of General Virology. 90 (11): 2686–2694. PMID 19625461.
- Frias-Staheli, N.; Giannakopoulos, N. V.; Kikkert, M.; Taylor, S. L.; Bridgen, A.; Paragas, J.; Richt, J. A.; Rowland, R. R.; Schmaljohn, C. S.; Lenschow, D. J.; Snijder, E. J.; García-Sastre, A.; Virgin, H. W. (2007). "Ovarian Tumor Domain-Containing Viral Proteases Evade Ubiquitin- and ISG15-Dependent Innate Immune Responses". Cell Host & Microbe. 2 (6): 404–416. PMID 18078692.
- Vigil, A.; Park, M. -S.; Martinez, O.; Chua, M. A.; Xiao, S.; Cros, J. F.; Martínez-Sobrido, L.; Woo, S. L. C.; García-Sastre, A. (2007). "Use of Reverse Genetics to Enhance the Oncolytic Properties of Newcastle Disease Virus". Cancer Research. 67 (17): 8285–8292. PMID 17804743.
- Mibayashi, M.; Martinez-Sobrido, L.; Loo, Y. -M.; Cardenas, W. B.; Gale, M.; Garcia-Sastre, A. (2006). "Inhibition of Retinoic Acid-Inducible Gene I-Mediated Induction of Beta Interferon by the NS1 Protein of Influenza a Virus". Journal of Virology. 81 (2): 514–524. PMID 17079289.
- Tumpey, T. M.; Maines, T. R.; Van Hoeven, N.; Glaser, L.; Solórzano, A.; Pappas, C.; Cox, N. J.; Swayne, D. E.; Palese, P.; Katz, J. M.; García-Sastre, A. (2007). "A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission". Science. 315 (5812): 655–659. S2CID 24627071.
- Richt, J. A.; Lekcharoensuk, P.; Lager, K. M.; Vincent, A. L.; Loiacono, C. M.; Janke, B. H.; Wu, W. -H.; Yoon, K. -J.; Webby, R. J.; Solórzano, A.; García-Sastre, A. (2006). "Vaccination of Pigs against Swine Influenza Viruses by Using an NS1-Truncated Modified Live-Virus Vaccine". Journal of Virology. 80 (22): 11009–11018. PMID 16943300.
- Tumpey, T. M.; Basler, C. F.; Aguilar, P. V.; Zeng, H.; Solórzano, A.; Swayne, D. E.; Cox, N. J.; Katz, J. M.; Taubenberger, J. K.; Palese, P.; García-Sastre, A. (2005). "Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus". Science. 310 (5745): 77–80. S2CID 14773861.
- Munoz-Jordan, J. L.; Sánchez-Burgos, G. G.; Laurent-Rolle, M.; García-Sastre, A. (2003). "Inhibition of interferon signaling by dengue virus". Proceedings of the National Academy of Sciences. 100 (24): 14333–14338. PMID 14612562.
- Basler, C. F.; Reid, A. H.; Dybing, J. K.; Janczewski, T. A.; Fanning, T. G.; Zheng, H.; Salvatore, M.; Perdue, M. L.; Swayne, D. E.; García-Sastre, A.; Palese, P.; Taubenberger, J. K. (2001). "Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses bearing the 1918 NS genes". Proceedings of the National Academy of Sciences. 98 (5): 2746–2751. PMID 11226311.
- Garciasastre, A. (2001). "Inhibition of Interferon-Mediated Antiviral Responses by Influenza a Viruses and Other Negative-Strand RNA Viruses". Virology. 279 (2): 375–384. PMID 11162793.
- Fodor, E.; Devenish, L.; Engelhardt, O. G.; Palese, P.; Brownlee, G. G.; García-Sastre, A. (1999). "Rescue of Influenza a Virus from Recombinant DNA". Journal of Virology. 73 (11): 9679–9682. PMID 10516084.
References
- ^ a b "RetroVirox". Retrieved 2 March 2010.
- ^ a b "Center for Investigating Viral Immunity & Antagonism". Archived from the original on 21 November 2008. Retrieved 2 March 2010.
- ^ "Founders and Scientific Advisory Board Page – Vivaldi Biosciences Inc". Retrieved 2 March 2010.
- ^ "Adolfo García-Sastre Lab". Retrieved 28 April 2015. Icahn School of Medicine at Mount Sinai
- ^ "Icahn School of Medicine at Mount Sinai - Faculty profile". Retrieved 15 April 2015.
- ^ "2019 NAS Election". www.nasonline.org. Retrieved 30 April 2019.
- ^ "Adolfo García-Sastre - Patents". Retrieved 2 March 2010.
- ^ "USPTO - Recombinant newcastle disease virus RNA expression systems and vaccines". Archived from the original on 21 November 2005.
- ^ "USPTO - NOVEL METHODS AND INTERFERON DEFICIENT SUBSTRATES FOR THE PROPAGATION OF VIRUSES".
- ^ "USPTO - Recombinant negative strand RNA virus expression systems and vaccines". Archived from the original on 21 November 2005.
- ^ "USPTO - Attenuated negative strand viruses with altered interferon antagonist activity for use as vaccines and pharmaceuticals". Archived from the original on 21 November 2005.
- ^ "USPTO - Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents". Archived from the original on 21 November 2005.
- ^ "USPTO - Genetically Engineered Swine Influenza Virus and Uses Thereof". Archived from the original on 21 November 2005.
- ^ "USPTO - Genetically Engineered Equine Influenza Virus and Uses Thereof". Archived from the original on 21 November 2005.
External links
- Icahn School of Medicine at Mount Sinai homepage
- The Global Health & Emerging Pathogens Institute at Icahn School of Medicine at Mount Sinai
- The Adolfo García-Sastre Lab at the Mount Sinai School of Medicine