Aedes aegypti

Source: Wikipedia, the free encyclopedia.

Yellow fever mosquito
Adult
Adult
Larva
Larva
Scientific classification Edit this classification
Domain: Eukaryota
Kingdom: Animalia
Phylum: Arthropoda
Class: Insecta
Order: Diptera
Family: Culicidae
Genus: Aedes
Subgenus: Stegomyia
Species:
A. aegypti
Binomial name
Aedes aegypti
(
Hasselquist, 1762) [1]
Subspecies[2][3]
  • Aedes aegypti aegypti
  • Aedes aegypti formosus
Global Aedes aegypti predicted distribution in 2015,
(blue=absent, red=present)
Synonyms[1]
  • Culex aegypti Linnaeus in Hasselquist, 1762
  • Culex fasciatus Fabricius, 1805
  • Culex bancrofti Skuse, 1889

Aedes aegypti (

thorax. This mosquito originated in Africa, but is now found in tropical
, subtropical and temperate regions throughout the world.

Biology

Male (left) and female (center and right) Ae. aegyptiE.A. Goeldi, 1905

Aedes aegypti is a 4–7 millimetres (5⁄32–35⁄128 in) long, dark

thorax. Females are larger than males. Microscopically females possess small palps tipped with silver or white scales, and their antennae have sparse short hairs, whereas those of males are feathery. Aedes aegypti can be confused with Aedes albopictus without a magnifying glass: the latter have a white stripe on the top of the mid thorax.[4]

Males live off fruit

odorant receptor AaegOr4.[10]
The white eggs are laid separately into water and not together, unlike most other mosquitoes, and soon turn black. The larvae feed on bacteria, growing over a period of weeks until they reach the pupa stage.[5]

The lifespan of an adult Ae. aegypti is two to four weeks depending on conditions,[11] but the eggs can be viable for over a year in a dry state, which allows the mosquito to re-emerge after a cold winter or dry spell.[12]

Hosts

Mammalian

equids more generally.[13]
As of 2009 birds were found to be the best food supply for Ae. aegypti among all taxa.[14]

Distribution

Ae. aegypti mosquito distribution in the United States, 2016

Aedes aegypti originated in Africa and was spread to the New World through slave trade,[15] but is now found in tropical, subtropical and temperate regions[16] throughout the world.[17] Ae. aegypti's distribution has increased in the past two to three decades worldwide, and it is considered to be among the most widespread mosquito species.[18]

In 2016,

Washington, DC, and genetic evidence suggests they survived at least the last four winters in the region. One of the study researchers noted, "...some mosquito species are finding ways to survive in normally restrictive environments by taking advantage of underground refugia".[19]
As the world's climate becomes warmer, the range of Aedes aegypti and a hardier species originating in Asia, the tiger mosquito Aedes albopictus, which can expand its range to relatively cooler climates, will inexorably spread north and south. Sadie Ryan of the University of Florida was the lead author in a 2019 study that estimated the vulnerability of naïve populations in geographic regions that currently do not harbor vectors i.e., for Zika in the Old World. Ryan's co-author, Georgetown University's Colin Carlson remarked,"Plain and simple, climate change is going to kill a lot of people."[20] As of 2020, the Northern Territory Government Australia and the Darwin City Council have recommended tropical cities initiate rectification programs to rid their cities of potential mosquito breeding stormwater sumps.[21] A 2019 study found that accelerating urbanization and human movement would also contribute to the spread of Aedes mosquitoes.[22]

In continental Europe, Aedes aegypti is not established but it has been found in localities close to Europe such as the Asian part of Turkey.[23] However, a single adult female specimen was found in Marseille (Southern France) in 2018. On the basis of a genetic study and an analysis of the movements of commercial ships, the origin of the specimen could be traced as coming from Cameroon, in Central Africa.[23]

Genomics

In 2007, the

The Institute for Genomic Research (now part of the J. Craig Venter Institute), the European Bioinformatics Institute, the Broad Institute, and the University of Notre Dame. The effort in sequencing its DNA was intended to provide new avenues for research into insecticides and possible genetic modification to prevent the spread of virus. This was the second mosquito species to have its genome sequenced in full (the first was Anopheles gambiae). The published data included the 1.38 billion base pairs containing the insect's estimated 15,419 protein-encoding genes. The sequence indicates the species diverged from Drosophila melanogaster (the common fruit fly) about 250 million years ago, and Anopheles gambiae and this species diverged about 150 million years ago.[24][25] Matthews et al., 2018 finds A. aegypti to carry a large and diverse number of transposable elements. Their analysis suggests this is common to all mosquitoes.[26]

Vector of disease

Aedes aegypti is a

vector for transmitting numerous pathogens. According to the Walter Reed Biosystematics Units as of 2022,[27]
it is associated with the following 54 viruses and 2 species of Plasmodium:

Aino virus (AINOV),

Yellow fever virus (YFV), Zegla virus (ZEGV), Zika virus, as well as Plasmodium gallinaceum and Plasmodium lophurae
.

This mosquito also

lumpy skin disease virus between cattle.[28][29]

The yellow fever mosquito can contribute to the spread of

Syrian hamsters.[30]

Bite prevention methods

The

mosquito repellents that contain DEET
(N, N-diethylmetatoluamide, 20% to 30%). It also suggests:

  1. Although Aedes aegypti mosquitoes most commonly feed at dusk and dawn, indoors, in shady areas, or when the weather is cloudy, "they can bite and spread infection all year long and at any time of day."[31][32]
  2. Once a week, scrub off eggs sticking to wet containers, seal or discard them. The mosquitoes prefer to breed in areas of
    stagnant water, such as flower vases, uncovered barrels, buckets, and discarded tires, but the most dangerous areas are wet shower floors and toilet tanks, as they allow the mosquitos to breed in the residence. Research has shown that certain chemicals emanating from bacteria in water containers stimulate the female mosquitoes to lay their eggs. They are particularly motivated to lay eggs in water containers that have the correct amounts of specific fatty acids associated with bacteria involved in the degradation of leaves and other organic matter in water. The chemicals associated with the microbial stew are far more stimulating to discerning female mosquitoes than plain or filtered water in which the bacteria once lived.[33]
  3. Wear long-sleeved clothing and long pants when outdoors during the day and evening.
  4. Use mosquito netting over the bed if the bedroom is not air conditioned or screened, and for additional protection, treat the mosquito netting with the insecticide permethrin.

Insect repellents containing DEET (particularly concentrated products) or

2-undecanone.[36]

Population control efforts

Insecticides

selective pressure under withdrawal of insecticide is hence limited.[37]

Genetic modification

Ae. aegypti has been

genetically modified to suppress its own species in an approach similar to the sterile insect technique, thereby reducing the risk of disease. The mosquitoes, known as OX513A, were developed by Oxitec, a spinout of Oxford University. Field trials in the Cayman Islands,[38] in Juazeiro,[39][40] Brazil,[38] by Carvalho et al., 2015,[39][40] and in Panama[38] by Neira et al., 2014[39] have shown that the OX513A mosquitoes reduced the target mosquito populations by more than 90%. This mosquito suppression effect is achieved by a self-limiting gene that prevents the offspring from surviving. Male modified mosquitoes, which do not bite or spread disease, are released to mate with the pest females. Their offspring inherit the self-limiting gene and die before reaching adulthood—before they can reproduce or spread disease. The OX513A mosquitoes and their offspring also carry a fluorescent marker for simple monitoring. To produce more OX513A mosquitoes for control projects, the self-limiting gene is switched off (using the Tet-Off system) in the mosquito production facility using an antidote (the antibiotic tetracycline), allowing the mosquitoes to reproduce naturally. In the environment, the antidote is unavailable to rescue mosquito reproduction, so the pest population is suppressed.[41]

The mosquito control effect is nontoxic and species-specific, as the OX513A mosquitoes are Ae. aegypti and only breed with Ae. aegypti. The result of the self-limiting approach is that the released insects and their offspring die and do not persist in the environment.[42][43]

In Brazil, the modified mosquitoes were approved by the National Biosecurity Technical Commission for releases throughout the country. Insects were released into the wild populations of Brazil, Malaysia, and the Cayman Islands in 2012.[44][45] In July 2015, the city of Piracicaba, São Paulo, started releasing the OX513A mosquitoes.[46][47] In 2015, the UK House of Lords called on the government to support more work on genetically modified insects in the interest of global health.[48] In 2016, the United States Food and Drug Administration granted preliminary approval for the use of modified mosquitoes to prevent the spread of the Zika virus.[49]

Another proposed method consists in using radiation to sterilize male larvae so that when they mate, they produce no progeny.[50] Male mosquitoes do not bite or spread disease.

Using CRISPR/Cas9 based genome editing to engineer the genome of Aedes aegypti genes like ECFP (enhanced cyan fluorescent protein), Nix (male-determining factor gene), Aaeg-wtrw (Ae. aegypti water witch locus), Kmo (kynurenine 3-monoxygenase), loqs (loquacious), r2d2 (r2d2 protein), ku70 (ku heterodimer protein gene) and lig4 (ligase4) were targeted to modify the genome of Aedes aegypti. The new mutant will become incapable of pathogen transmission or result in population control.[51]

Infection with Wolbachia

In 2016 research into the use of a bacterium called

Alphabet, Inc. started the Debug Project to infect males of this species with Wolbachia bacteria, interrupting the reproductive cycle of these animals.[55]

Fungus infection

Fungal species Erynia conica (from the family Entomophthoraceae) infects (and kills) two types of mosquitos: Aedes aegypti and Culex restuans. Studies on the fungus have been carried out on its potiential use as a biological control of the mosquitos.[56]

Taxonomy

The species was first named (as Culex aegypti) in 1757 by

zoological nomenclature in 1758. Nonetheless, the name Aedes aegypti was frequently used, starting with H. G. Dyar in 1920.[citation needed
]

Ae. aegypti feeding on a human

To stabilise the nomenclature, a petition to the International Commission on Zoological Nomenclature was made by P. F. Mattingly, Alan Stone, and Kenneth L. Knight in 1962.[59] It also transpired that, although the name Aedes aegypti was universally used for the yellow fever mosquito, Linnaeus had actually described a species now known as Aedes (Ochlerotatus) caspius.[59] In 1964, the commission ruled in favour of the proposal, validating Linnaeus' name, and transferring it to the species for which it was in general use.[60]

The yellow fever mosquito belongs to the tribe Aedini of the dipteran family

Culicidae and to the genus Aedes and subgenus Stegomyia. According to one recent analysis, the subgenus Stegomyia of the genus Aedes should be raised to the level of genus.[61] The proposed name change has been ignored by most scientists;[62] at least one scientific journal, the Journal of Medical Entomology, has officially encouraged authors dealing with aedile mosquitoes to continue to use the traditional names, unless they have particular reasons for not doing so.[63] The generic name comes from the Ancient Greek ἀηδής, aēdēs, meaning "unpleasant"[64]
or "odious".

Subspecies

Two subspecies are commonly recognized:

  • Aedes aegypti subsp. aegypti[2][3]
  • Aedes aegypti subsp. formosus[2][3]

This classification is complicated by the results of Gloria-Soria et al., 2016. Although confirming the existence of these two major subspecies, Gloria-Sora et al. finds greater worldwide diversity than previously recognized and a large number of distinct populations separated by various geographic factors.[2][3]

References

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