Aeruginascin

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Aeruginascin
Clinical data
ATC code
  • none
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
  • UK: Class A
Identifiers
  • [3-[2-(Trimethylazaniumyl)ethyl]-1H-indol-4-yl] hydrogen phosphate
JSmol)
  • C[N+](C)(C)CCc1c[nH]c2c1c(ccc2)OP(=O)(O)[O-]
  • InChI=1S/C13H19N2O4P/c1-15(2,3)8-7-10-9-14-11-5-4-6-12(13(10)11)19-20(16,17)18/h4-6,9,14H,7-8H2,1-3H3,(H-,16,17,18) checkY
  • Key:OIIPFLWAQQNCHA-UHFFFAOYSA-N checkY
  (verify)

Aeruginascin or N,N,N-trimethyl-4-phosphoryloxytryptamine is an

analogue of psilocybin. It is closely related to the frog skin toxin bufotenidine (5-HTQ), a potent 5-HT3 receptor agonist, but the aeruginascin metabolite 4-HO-TMT shows strong binding at the 5-HT2 receptors similar to psilocin.[8][9] The first scientific literature about the pharmacological effects of aeruginascin is from a study published by Gartz in 1989.[10] Across 23 analyzed cases of accidental hallucinogenic mushroom poisonings, people who had ingested the mushroom Inocybe aeruginascens reported only euphoric experiences.[11]
This is in contrast to the slight and in some cases extremely dysphoric experiences reported from the accidental ingestion of non aeruginascin containing mushrooms (containing solely psilocybin and psilocin).

Inocybe aeruginascens

References

  1. ^ Gartz J (1995). "Inocybe aeruginascens Babos". Eleusis, Journal of Psychoactive Plants & Compounds. 3. Museo Civico di Rovereto: 31–4.
  2. S2CID 260281286. Archived from the original
    (PDF) on 2011-05-24.
  3. S2CID 211214973
    .
  4. PMID 22957740
    .
  5. PMID 30875889
    .
  6. ^
    PMID 36430546
    .
  7. ^ "CaaMTech Publishes Fundamental Research on Aeruginascin Derivatives". 14 September 2022.
  8. PMID 32685863
    .
  9. ^ Bauer BE (2020-07-07). "Study Finds Aeruginascin Metabolite 4-HO-TMT is Active at the Serotonin 5-HT2A Receptor". Psychedelic Science Review. Archived from the original on 2020-08-05. Retrieved 2021-09-07.
  10. ISSN 0167-7314
    .
  11. ^ "Aeruginascin". Psychedelic Science Review. 2018-11-19. Retrieved 2021-09-07.
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