Albert Stevens

Source: Wikipedia, the free encyclopedia.
For other people named Albert Stevens, see Albert Stevens (disambiguation).
Albert Stevens
Cremains in storage at Argonne National Laboratory and Washington State University
NationalityAmerican
Other namesAlbert
OccupationHouse painter
Known forSurviving the highest known radiation dose in any human

Albert Stevens (1887–1966), also known as patient CAL-1 and most radioactive human ever, was a house painter from

kBq (3.55 μCi) of plutonium without his knowledge because it was erroneously believed that he had a terminal disease.[2]

Plutonium remained present in his body for the remainder of his life, the amount decaying slowly through

μSv/h. The current annual permitted dose for a radiation worker in the United States is 0.05 Sv (or 5 rem), i.e. an average of 5.7 μSv/h.[3]

Background

Plutonium was first synthesized in 1940 and isolated in 1941 by chemists at the

plutonium cored nuclear weapons that were being developed as part of the Manhattan Project. Of the three nuclear weapons made during the war, two of them used plutonium as their fissile material
.

Plutonium was handled extensively by chemists, technicians, and physicists taking part in the Manhattan Project, but the effects of plutonium exposure on the human body were largely unknown.[2] A few mishaps in 1944 had caused certain alarm amongst project leaders, and contamination was becoming a major problem in and outside the laboratories.[2] Plutonium was tracked into civilian areas, plutonium dust was being inhaled by workers, and accidental ingestion was a grave concern for those who routinely handled it. In August 1944, a chemist named Donald Mastick was sprayed in the face with liquid plutonium chloride, causing him to accidentally swallow some.[2][6]

Manhattan Project

body burden per day is typical, 2 to 3 weeks after exposure.[2]

As the

transuranium elements including plutonium, urged him that a safety program be developed and suggested: "that a program to trace the course of plutonium in the body be initiated as soon as possible ... [with] the very highest priority."[8]

Tracer experiments were begun in 1944 with rats and other animals with the knowledge of all of the Manhattan Project managers and health directors of the various sites. In 1945, human tracer experiments began with the intent to determine how to properly analyze excretion samples to estimate body burden. Numerous analytic methods were devised by the lead doctors at the Met Lab (Chicago),

Billings Hospital in Chicago, and May 14 at the University of California Hospital in San Francisco. Albert Stevens was the person selected in the California test and designated CAL-1 in official documents.[2]

Buchenwald touch."[9]

The plutonium experiments were not isolated events.[2] During this time, cancer researchers were attempting to discover whether certain radioactive elements might be useful to treat cancer.[2] Recent studies on radium, polonium, and uranium proved foundational to the study of Pu toxicity. For example, polonium (another alpha emitter) research indicated that test sample contamination was a major concern, which is why a cleanroom had to be established at Los Alamos in February 1945 in the Medical Labs Building.[2]

Behind this human experiment with plutonium was Dr. Joseph Gilbert Hamilton, a Manhattan Project doctor in charge of the human experiments in California.[8] Hamilton had been experimenting on people (including himself) since the 1930s at Berkeley. He was working with other Manhattan Project doctors to perform toxicity studies on plutonium. It was Hamilton who had begun the 1944 tracer experiments on rats. The opportunity to select a human patient was relatively easy: Hamilton was not only a physicist assigned to U.C. Berkeley, he was "professor of experimental medicine and radiology" at U.C. San Francisco."[1] Hamilton eventually succumbed to the radiation that he explored for most of his adult life: he died of leukemia at the age of 49.

Although Stevens was the person who received the highest dose of radiation during the plutonium experiments, he was neither the first nor the last subject to be studied. Eighteen people aged 4 to 69 were injected with plutonium. Subjects who were chosen for the experiment had been diagnosed with a terminal disease. They lived from six days up to 44 years past the time of their injection.[2] Eight of the 18 died within two years of the injection.[2] All died from their preexisting terminal illness or cardiac illnesses. None died from the plutonium itself. Patients from Rochester, Chicago, and Oak Ridge were also injected with plutonium in the Manhattan Project human experiments.[1][2][8]

As with all radiological testing during World War II, it would have been difficult to receive informed consent for Pu injection studies on civilians. Within the Manhattan Project, plutonium was referred to often by its code designation "49" (from its atomic number 94 and its atomic mass 239) or simply the "product". Few outside of the Manhattan Project would have known of plutonium, much less of the dangers of radioactive isotopes inside the body. There is no evidence that Stevens had any idea that he was the subject of a secret government experiment in which he would be subjected to a substance that would have no benefit to his health.[2][8]

Experiment on Stevens

Stevens was a house painter, originally from

gastric ulcer that was misdiagnosed as terminal cancer. According to Earl Miller, acting chief of radiology at the time, he was chosen for this study because "he was doomed" to die.[1]

Stevens was injected with a mixture of plutonium isotopes having the Pu(VI) chemical species (Pu+6) as the nitrate PuO2(NO3)2.

U.C. San Francisco radiologist Earl Miller injected the plutonium into Albert's body.[1] Scott transported the plutonium from the lab to the hospital where Albert Stevens was being treated for stomach cancer. Miller repeatedly denied that he injected plutonium.[1]

According to Scott, "[Albert Stevens] got many times the so-called lethal textbook dose of plutonium."[1]

Although the original estimates (and some later figures) concerning the activity of the injected solution were erroneous, modern research indicates that Stevens (who weighed 58 kilograms (128 lb))

Pu-238 (produced in the 60-inch cyclotron at the Crocker Laboratory by deuteron bombardment of natural uranium)[10] contributed heavily to his long-term dose. Had all of the plutonium given to Stevens been the long-lived Pu-239 as used in similar experiments of the time, Stevens's lifetime dose would have been significantly smaller. The short half-life
of 87.7 years of Pu-238 means that a large amount of it decayed during its time inside his body, especially when compared to the 24,100 year half-life of Pu-239.

When specimens were taken during Stevens's cancer surgery, Earl Miller took them for radiological testing; Scott collected urine and stool samples.

chronic inflammation."[8] The hospital staff reacted with disbelief. There had been no reason for surgery, although the size of the inflammation was extraordinary. There had also been no therapeutic intent for the experiment,[8][11] although surgeons assumed that Stevens had received radioactive phosphorus for "special studies".[1]

While at the hospital, "both a radiologist and a surgical consultant concluded that Albert probably had cancer but suggested a

gastroscopy be done to confirm the diagnosis."[1] This had never been done. Prior to Stevens's trip to the hospital, "A local physician suspected Albert had a malignant ulcer that had spread to the liver and advised him to consult specialists at the University of California Hospital."[1] Stevens's surgeons found a "huge, ulcerating, carcinomatous mass that had grown into his spleen and liver... Half of the left lobe of the liver, the entire spleen, most of the ninth rib, lymph nodes, part of the pancreas, and a portion of the omentum... were taken out"[1]
to help prevent the spread of cancer that Stevens did not have.

After surgery

Once Stevens was out of surgery, his urine and stool samples were analyzed for plutonium activity. The Pu-238 helped the researchers in this respect because it was much easier to detect. But as Stevens's condition improved and his medical bills soared, he was sent home to recover. The Manhattan District decided to pay for his urine and stool samples to keep him close to San Francisco on the pretext that his "cancer" surgery and remarkable recovery were being studied.[1]

According to Stevens's surviving son Thomas, Stevens kept samples in a shed behind his house for storage; an intern and a nurse would pick them up once a week.

lumbar region of his spine and several degenerating discs."[1] Plutonium, like radium and many other heavy metals, accumulates in the bones.[2][10]

None of the people at UCSF or those who treated Stevens ever explained to Stevens that he did not have cancer, nor did they disclose to him that he was a part of an experiment; his wife and daughter "figured they were using him for a guinea pig", but that the experimental treatment had worked.[1] Thomas Stevens, Albert's son, always filled out medical forms indicating that there was a "history of cancer" in his family because his father had been led to believe that the "treatment" for his cancer had worked.[1]

Stevens received approximately 6400

rem (64 Sv) in the 20 years after his injection, or about 300 rem (3 Sv) per year.[1] The annual, whole-body dose currently permitted to radiation workers in the United States is 5 rem;[12]
Stevens's total dose was approximately 60 times this amount.

He died on January 9, 1966, of

cardiorespiratory failure[1][10] (heart disease)[2] at the age of 79. His cremated remains were shipped to the Argonne National Laboratory Center for Human Radiobiology in 1975, but they were never returned to the chapel which held them from 1966 to 1975. Some of the ashes were transferred to the National Human Radiobiology Tissue Repository at Washington State University,[1]
which keeps the remains of people who died having radioisotopes in their body.

In a 1975 study of the eighteen people who received plutonium injections in

carcinogenic. However, no bone tumors have yet appeared."[10]
The word "yet" reflected the fact that four other subjects were still alive in 1975.

Investigative journalism

Hazel O'Leary, publicly stated that the government should compensate victims. Responding to the issues revealed by Welsome, President Bill Clinton ordered the formation of the Advisory Committee on Human Radiation Experiments on January 15, 1994, to investigate.[13] Welsome was highly critical of the committee's final report, which was released in 1995.[1]

See also

References

  1. ^
    ISBN 978-0385314022
    . Retrieved 18 November 2012.
  2. ^ a b c d e f g h i j k l m n o p q r s t u Moss, William; Eckhardt, Roger (1995). "The Human Plutonium Injection Experiments" (PDF). Los Alamos Science. Radiation Protection and the Human Radiation Experiments (23): 177–223. Retrieved 13 November 2012.
  3. ^ "Information for Radiation Workers". NRC Web. Retrieved 2022-11-18.
  4. ^ Seaborg, Glenn T. "An Early History of LBNL: Elements 93 and 94". Advanced Computing for Science Department, Lawrence Berkeley National Laboratory. Archived from the original on November 5, 2014. Retrieved September 17, 2008.
  5. ^ Glenn T. Seaborg (September 1981). "The plutonium story". Lawrence Berkeley Laboratory, University of California. LBL-13492, DE82 004551.
  6. ^ After immediate treatment including scrubbing, stomach pumping, and citrate chelation (see Donald Mastick), less than 1 microgram of plutonium remained in his body. He lived to the age of 87.
  7. ^ a b c Plutonium in Man: A Twenty-Five Year Review, UCRL 20850, TID-4500 (58th Ed.), Patricia W. Durbin, 1971.
  8. ^ a b c d e f g Final Report Archived 2013-02-24 at the Wayback Machine, Advisory Committee on Human Radiation Experiments, 1985
  9. ^ "The Media & Me: [The Radiation Story No One Would Touch]", Geoffrey Sea, Columbia Journalism Review, March/April 1994.
  10. ^ a b c d e f g h Rowland, R.E., and Durbin, P.W. Survival, causes of death, and estimated tissue doses in a group of human beings injected with plutonium. United States: N. p., 1975. Web.
  11. ^ a b The Plutonium Files: America's secret medical experiments in the Cold War (Book Review) The New England Journal of Medicine, Volume 341:1941-1942, Harriet A. Washington, December 16, 1999.
  12. ^ "Information for Radiation Workers". United States Nuclear Regulatory Commission. March 29, 2012. Retrieved February 4, 2013.
  13. ^ a b Alterman, Eric (February 11, 2000). "The Plutonium Files". The Nation. Archived from the original on 2013-05-28. Retrieved 2013-02-12.

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Albert_Stevens&oldid=1219831092"