Alder–Reilly anomaly
Alder–Reilly anomaly, or Alder anomaly, is an inherited abnormality of
lymphocytes. The condition may be mistaken for toxic granulation, a type of abnormal granulation in neutrophils that occurs transiently in inflammatory conditions.[1][2]: 477 [3]
In addition to mucopolysaccharidosis, Alder–Reilly anomaly may occur in
carriers who are heterozygous for the Tay–Sachs mutation, although the inclusions are much less frequent than in homozygotes.[5]: 124 Alder–Reilly anomaly is not diagnostic of any disorder and does not correlate with disease severity.[4]: 32 Affected white blood cells function normally.[2]
: 477
Alder–Reilly inclusions stain appear violet when treated with
Wright–Giemsa stain and, in mucopolysaccharidosis, stain metachromatically with toluidine blue. Metachromatic staining is not seen in Tay–Sachs disease. The granules tend to be round or comma-shaped and may be surrounded by a clearing in the cytoplasm.[5]
: 124
References
- ^ ISBN 978-1-4963-6713-6.
- ^ ISBN 978-0-323-23906-6.
- American Association for Clinical Chemistry (2018-12-09). "Blood Smear". Lab Tests Online. Retrieved 2019-12-25.
- ^ ISBN 978-3-642-18799-5.
- ^ ISBN 978-1-118-81729-2.
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