Alejandro Zaffaroni

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Alejandro Zaffaroni
Biotechnology Heritage Award, 2006
Born(1923-02-27)February 27, 1923
Montevideo, Uruguay
DiedMarch 1, 2014(2014-03-01) (aged 91)
Atherton, California, US
Alma mater
SpouseLida Zaffaroni
Scientific career
ThesisThe Application of Paper Partition Chromatography to Steroid Analysis (1950)

Alejandro Zaffaroni (February 27, 1923 – March 1, 2014) was a Uruguayan

corticosteroids, and the DNA microarray.[4]

Education

Zaffaroni was born on February 27, 1923, in

University of the Republic in 1945, and his Ph.D. in biochemistry from the University of Rochester in 1949.[5]

Career

Zaffaroni joined

Palo Alto
, California. He was appointed president of the U.S. subsidiary in 1962.

In 1968, he founded

controlled drug delivery. He modeled new delivery systems after the processes discovered in endocrinology – where glands deliver very small amounts of hormones but have a tremendous effect –.[6]

ALZA's first controlled drug delivery product was used to treat

Transderm-Scop, to prevent nausea and vomiting associated with motion sickness.[7]

In 1980, Zaffaroni established DNAX, a developer of

immunobiology.[8]

In 1988 he co-founded Affymax, specializing in combinatorial chemistry to reduce the cost and time of identifying new medicines.

In 1991 he co-founded Affymetrix,[9] specializing in using genetics for developing new medicine. He was also involved in the creation of Perlegen Sciences, an Affymetrix spin-off which works on finding genetic causes of disease.

In 1994, he founded Symyx Technologies, a company dedicated to utilizing combinatorial chemistry technologies.

Other companies he founded include Maxygen (1997), a developer of technologies that improve the development of proteins and genetic elements, and SurroMed, focusing on the development of technologies for surrogate disease markers. In 2000, he founded Alexza Pharmaceuticals, a company working on rapid onset of action drug delivery technologies.

He died at his home at Atherton, California, on March 1, 2014. He was 91.[10]

Awards and honors

Alejandro Zaffaroni receiving the Winthrop–Sears Medal, 2004

In 1979 Zaffaroni was awarded the

Chemical Heritage Foundation.[12][13]

References

  1. PMID 24717508
    .
  2. ^ Alejandro Zaffaroni's publications indexed by the Scopus bibliographic database. (subscription required)
  3. PMID 14907764
    .
  4. ^ Pollack, Andrew (March 6, 2014). "Alejandro Zaffaroni, Entrepreneur on Biotech Frontier, Dies at 91". The New York Times. Retrieved 17 March 2016.
  5. ^ Inventor of the Week: Alejandro Zaffaroni
  6. ^ The Revolutionaries: Alejandro Zaffaroni Archived 2014-05-13 at the Wayback Machine
  7. ^ ALZA: Commercial Products[permanent dead link]
  8. ^ Palo Alto to be home of expanded biopharma research effort
  9. ^ "Affymetrix CEO opens his wallet". mercurynews.com. 11 May 2008. Retrieved 2022-09-06.
  10. ^ Alejandro Zaffaroni, longtime friend of Stanford, deceased at 91
  11. ^ "Chemical Pioneer Award". American Institute of Chemists. Retrieved 30 November 2015.
  12. ^ "Biotechnology Heritage Award". Science History Institute. 31 May 2016. Retrieved 21 February 2018.
  13. ^ Gussman, Neil (9 April 2006). "Alejandro Zaffaroni Receives 2006 Biotechnology Heritage Award". BIO. Retrieved 5 February 2014.
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