Ameloblastic carcinoma

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Ameloblastic carcinoma
SpecialtyOncology

Ameloblastic carcinoma is a rare form of malignant

epithelial cells that generate the tooth enamel. It is usually treated with surgery; chemotherapy has not been proven to be effective.[1][2]

Signs and Symptoms

Common symptoms of ameloblastic carcinomas are pain and swelling either localized in the jaw or throughout the entire face, dysphagia, and

epistaxis, facial pressure, and nasal dyspnea.[3][4]

Causes

It is speculated that some cases of ameloblastic carcinoma arise from remnants of epithelial tissue left behind after the development of the teeth and related structures. Other times, it may be caused by a benign odontogenic cyst becoming malignant, or a pre-existing ameloblastoma.[5][2]

Treatment

Chemotherapy has not proven effective in treating ameloblastic carcinoma, leaving surgical removal of the tumor one of the only options.[6] Surgical resection with wide margins is the main treatment.[7]

Prognosis

Followup after surgery is important, as over 50% of recurrences occur within 5 years.[6]

References

  1. ^ "Ameloblastic Carcinoma - NORD (National Organization for Rare Disorders)". Retrieved 2015-09-22.
  2. ^
    PMID 22190836
    .
  3. PMID 31903302
    .
  4. S2CID 239442287
    .
  5. ^ "Ameloblastic Carcinoma - NORD (National Organization for Rare Disorders)". Retrieved 2020-12-07.
  6. ^
    PMID 7633291
    .
  7. PMID 30509051
    .

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Ameloblastic_carcinoma&oldid=1202115701"