Amentoflavone

Source: Wikipedia, the free encyclopedia.
Amentoflavone
Skeletal formula
Ball-and-stick model of amentoflavone
Names
IUPAC name
(4′,5,7-Trihydroxyflavone)-(3′→8)-(4′,5,7-trihydroxyflavone)
Systematic IUPAC name
8-[5-(5,7-Dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
Other names
Didemethyl-ginkgetin
3′,8″-Biapigenin
Identifiers
3D model (
JSmol
)
ChEMBL
ChemSpider
KEGG
UNII
  • InChI=1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H checkY
    Key: YUSWMAULDXZHPY-UHFFFAOYSA-N checkY
  • InChI=1/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H
    Key: YUSWMAULDXZHPY-UHFFFAOYAB
  • O=C1\C=C(/Oc2cc(O)cc(O)c12)c6cc(c5c(O)cc(O)c3c5O/C(=C\C3=O)c4ccc(O)cc4)c(O)cc6
Properties
C30H18O10
Molar mass 538.464 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Amentoflavone is a biflavonoid (bis-apigenin coupled at 8 and 3′ positions, or 3′,8″-biapigenin) constituent of a number of plants including

Xerophyta plicata.[3]

Amentoflavone can interact with many medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are enzymes responsible for the metabolism of some drugs in the body.[4] It is also an inhibitor of human cathepsin B.[2]

Amentoflavone has a variety of

negative allosteric modulator.[10]

See also

References

  1. PMID 35002708.{{cite journal}}: CS1 maint: date and year (link
    )
  2. ^
    PMID 16084098
    .
  3. doi:10.1016/S0031-9422(00)83875-3
    .
  4. PMID 19883715
    .
  5. ^ "Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP)".
  6. PMID 19652385
    .
  7. S2CID 254054659
    .
  8. S2CID 26035868
    .
  9. PMID 17685652
    .
  10. PMID 12824018
    .

External links
Retrieved from "https://en.wikipedia.org/w/index.php?title=Amentoflavone&oldid=1190666599"