Amide reduction

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Amide reduction is a reaction in

reduced to either an amine or an aldehyde functional group.[1][2]

Catalytic hydrogenation

Catalytic

atm and temperatures exceeding 200 °C).[1] Selective catalysts for the reaction include copper chromite, rhenium trioxide and rhenium(VII) oxide or bimetallic catalyst.[3][4][5]

Amines from other hydride sources

Reduction of amides to amines

Iron catalysis by triiron dodecacarbonyl in combination with polymethylhydrosiloxane has been reported.[12]


Noncatalytic routes to aldehydes

Some amides can be reduced to aldehydes in the

Sonn-Müller method
, but most routes to aldehydes involve a well-chosen organometallic reductant.

Lithium aluminum hydride reduces an excess of N,N-disubstituted amides to an aldehyde:[citation needed]

R(CO)NRR' + LiAlH4 → RCHO + HNRR'

With further reduction the

alcohol
is obtained.

Schwartz's reagent reduces amides to aldehydes,[13] and so does hydrosilylation with a suitable catalyst.

References

External links