Aminocaproic acid

Source: Wikipedia, the free encyclopedia.

Aminocaproic acid
Skeletal formula
Ball-and-stick model of the zwitterionic form of the molecule found in the crystal structure[1][2]
Clinical data
Trade namesAmicar
AHFS/Drugs.comMonograph
MedlinePlusa608023
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
MetabolismKidney
Elimination half-life2 hours
Identifiers
  • 6-aminohexanoic acid
JSmol)
Melting point205 °C (401 °F)
  • C(CCC(=O)O)CCN
  • InChI=1S/C6H13NO2/c7-5-3-1-2-4-6(8)9/h1-5,7H2,(H,8,9) checkY
  • Key:SLXKOJJOQWFEFD-UHFFFAOYSA-N checkY
  (verify)

Aminocaproic acid (also known as ε-aminocaproic acid, ε-Ahx, or 6-aminohexanoic acid) is a derivative and analogue of the

Nylon-6, where it is formed by ring-opening hydrolysis of caprolactam. The crystal structure determination showed that the 6-aminohexanoic acid is present as a salt, at least in the solid state.[4]

Medical use

Aminocaproic acid (Amicar) is FDA-approved for use in the treatment of acute bleeding due to elevated fibrinolytic activity.

promyelocytic leukemia.[12]

References

  1. doi:10.5517/ccv38nv
    . Retrieved 18 August 2021.
  2. doi:10.1107/S0365110X67003019
    .
  3. ^ a b c "Amicar- aminocaproic acid solution Amicar- aminocaproic acid tablet". DailyMed. 9 October 2020. Retrieved 11 November 2020.
  4. doi:10.5517/ccv38nv
    , retrieved 24 October 2019
  5. ^ "Aminocaproic acid Orphan Drug Designations and Approvals". U.S. Food and Drug Administration (FDA). 6 January 1995. Retrieved 11 November 2020.
  6. PMID 9298049
    .
  7. PMID 2774776
    .
  8. PMID 6782532
    .
  9. PMID 26339364
    .
  10. PMID 7580358
    .
  11. S2CID 33961815
    .
  12. PMID 18613223
    .

Further reading
Retrieved from "https://en.wikipedia.org/w/index.php?title=Aminocaproic_acid&oldid=1218894996"