Amylin Pharmaceuticals
US$651 million (2011)[2] | |
US$−543 million (2011)[2] | |
Total assets | US$1.87 billion (2011)[2] |
Total equity | US$−139 million (2011)[2] |
Number of employees | 1,300 (2011)[2] |
Subsidiaries | Amylin Ohio LLC |
Amylin Pharmaceuticals, Inc. is a
History
1987–1992: Founding and IPO
In 1987, Amylin Pharmaceuticals was co-founded by Howard E. Greene Jr., former CEO of
1992–1998: Invention of Pramlintide and partnership with Johnson & Johnson
Amylin, in its natural form, is sticky, clumping on needles and forming little rocks[clarification needed] in the pancreas. To create a synthetic version that was more reliable and easy to work with, researchers at Amylin Pharmaceuticals altered amino acids in the molecule. The result was a new drug named pramlintide.[5]
In 1995, Amylin Pharmactietucals signed an agreement with
Initial Phase III trial results released in August 1997 demonstrated statistically significant results for
1998–2005: New Leadership, struggle to launch Pramlintide, and development of Byetta
Joseph C. Cook Jr., a 28-year veteran at Eli Lilly & Co. and an Amylin board member since 1994, came out of retirement in 1998, taking the title of chief executive officer. Cook reduced the company's workforce by 75 percent to conserve cash and raised capital from investors to keep Symlin moving through the regulatory pipeline.[4]
Symlin (pramlintide)
In October 2001, Amylin received an
Byetta (Exenatide)
In October 1996, Dr. John Eng licensed to Amylin exendin-4, a peptide he had isolated in the venom of a
2005–2009: Development of Bydureon and proxy battle
2011–2012: End of collaboration with Eli Lilly and acquisition
In July 2012,
In December 2013, AstraZeneca purchased the Bristol-Myers Squibb share of the diabetes joint venture, and as a result, became the sole owner of all former Amylin products and business, including the manufacturing facility in West Chester, Ohio.[20][21]
On February 4, 2014, the U.S. FDA approved Myalept (metreleptin), an analog of human leptin,[22] as replacement therapy to treat the complications of leptin deficiency, in addition to diet, in patients with congenital generalized or acquired generalized lipodystrophy.[23] Metraleptin was originally developed at Amylin Pharmaceuticals.[24] In November 2014, Aegerion Pharmaceuticals made a $325 million cash payment to AstraZeneca to acquire and commercialize metreleptin.[25]
References
- ^ "Company Profile for Amylin Pharmaceuticals Inc (AMLN)". Retrieved 2008-10-21.
- ^ a b c d e "Form 10-K". www.sec.gov. Retrieved 2017-05-26.
- ^ "Howard E. Greene Jr. - Executive Bio, Compensation History, and Contacts - Equilar Atlas". people.equilar.com. Archived from the original on 2016-08-13. Retrieved 2017-05-26.
- ^ a b "History of Amylin Pharmaceuticals, Inc. – FundingUniverse". www.fundinguniverse.com. Retrieved 2017-05-26.
- ISSN 0362-4331. Retrieved 2017-05-26.
- ISSN 0362-4331. Retrieved 2017-05-26.
- ^ Moukheiber, Zina (2000-07-24). "Roller Coasting". Forbes. Retrieved 2017-05-26.
- ^ "The Motley Fool, 3/20/98: The Daily Trouble". www.fool.com. Archived from the original on 2006-03-08. Retrieved 2017-05-26.
- ^ Letter, The Pharma. "Amylin to take Symlin back to clinic - Pharmaceutical industry news". www.thepharmaletter.com. Retrieved 2017-05-26.
- ^ Letter, The Pharma. "Amylin's Symlin US approval on hold - Pharmaceutical industry news". www.thepharmaletter.com. Retrieved 2017-05-26.
- ^ "FDA Approves Symlin for Type 1 and Type 2 Diabetes". 2005-03-18. Retrieved 2017-05-26.
- ^ a b "Dr. John Eng's Research Found That The Saliva Of The Gila Monster Contains A Hormone That Treats Diabetes Better Than Any Other Medicine". Diabetes In Control. A free weekly diabetes newsletter for Medical Professionals. 2007-09-18. Retrieved 2017-05-26.
- PMID 21525469.
- ISSN 0458-3035. Retrieved 2017-05-26.
- ^ "Diabetes Drug Byetta Gets FDA Approval". Retrieved 2017-05-26.
- ^ Shannon Pettypiece (3 July 2012). "Bristol's Amylin Deal Heralds Acquisition Hunger". Bloomberg.com. Retrieved 21 February 2015.
- ^ Pollack, Michael J. de la Merced and Andrew (30 June 2012). "Bristol-Myers in Deal for Amylin Valued at $7 Billion". DealBook. Retrieved 2017-05-25.
- ^ Fikes, Bradley J. "Amylin's San Diego operations closing". sandiegouniontribune.com. Retrieved 2017-05-25.
- ^ "Amylin Pharmaceuticals to Be Closed | San Diego Business Journal". www.sdbj.com. 3 April 2013. Retrieved 2017-05-25.
- ^ Allison Connolly (19 December 2013). "AstraZeneca to Acquire Bristol Stake in Diabetes Venture". Bloomberg.com. Retrieved 21 February 2015.
- ^ "Business as usual at Amylin plant during sale". daytondailynews. Retrieved 2017-05-25.
- ^ Lipodystrophy Orphan Drug Program. Amylin Pharmaceuticals.
- ^ U.S. Food and Drug Administration (25 February 2014). "FDA approves Myalept to treat rare metabolic disease". News & Events: Press Announcements. Retrieved 22 June 2015.
- ^ "Amylin and Takeda Suspend Obesity Study to Consider Metreleptin Data | Xconomy". Xconomy. 2011-03-16. Retrieved 2017-05-25.
- ^ "Struggling Aegerion Diversifies With Fat Disease Drug | Xconomy". Xconomy. 2014-11-06. Retrieved 2017-05-25.