Anatomical pathology

Her2neu

. The dark-brown reaction indicates that this tumor over-expresses this gene.

dura lifted by the forceps), the result of bacterial meningitis

.

lung showing the honeycomb pattern of end-stage pulmonary fibrosis

.

colon

mucosa (the horizontal line at the bottom).

Anatomical pathology (Commonwealth) or anatomic pathology (U.S.) is a medical specialty that is concerned with the diagnosis of disease based on the

Anatomical pathology is one of two branches of

.

Differences with clinical pathology

Anatomic pathology relates to the processing, examination, and diagnosis of surgical specimens by a physician trained in pathological diagnosis. Clinical pathology involves the laboratory analysis of tissue samples and bodily fluids; procedures may include blood sample analysis, urinalysis, stool sample analysis, and analysis of spinal fluid. Clinical pathologists may specialize in a number of areas, including blood banking, clinical chemistry, microbiology, and hematology.^[3]

The procedures used in anatomic pathology include:

• Gross examination – the examination of diseased tissues with the naked eye. This is important especially for large tissue fragments, because the disease can often be visually identified. It is also at this step that the pathologist selects areas that will be processed for histopathology. The eye can sometimes be aided with a magnifying glass or a stereo microscope
  , especially when examining parasitic organisms.
• histochemistry
  .
• Immunohistochemistry – the use of antibodies to detect the presence, abundance, and localization of specific proteins. This technique is critical to distinguishing between disorders with similar morphology, as well as characterizing the molecular properties of certain cancers.
• FISH
  .
• Cytopathology – the examination of loose cells spread and stained on glass slides using cytology techniques
• immotile cilia syndrome
  .
• Tissue cytogenetics – the visualization of chromosomes to identify genetic defects such as chromosomal translocation
• immunophenotype of cells using flow cytometry techniques. It is very useful to diagnose the different types of leukemia and lymphoma
  .

Subspecialties

Surgical pathology

. Surgical pathology increasingly requires technologies and skills traditionally associated with clinical pathology such as molecular diagnostics.

In the United States, subspecialty-trained doctors of dentistry, rather than medical doctors, can be certified by a professional board to practice Oral and Maxillofacial Pathology.

, non-physician cytotechnologists are often employed to perform initial reviews, with only positive or uncertain cases examined by the pathologist. Cytopathology is a board-certifiable subspecialty in the U.S.

Molecular pathology is an emerging discipline within anatomical and clinical pathology that is focused on the use of nucleic acid-based techniques such as in-situ hybridization, reverse-transcriptase polymerase chain reaction, and nucleic acid microarrays for specialized studies of disease in tissues and cells. Molecular pathology shares some aspects of practice with both anatomic and clinical pathology, and is sometimes considered a "crossover" discipline.

Forensic pathologists receive specialized training in determining the cause of death and other legally relevant information from the bodies of persons who died suddenly with no known medical condition, those who die from non-natural causes, as well as those dying as a result of homicide, or other criminally suspicious deaths. A majority of the forensic pathologists cases are due to natural causes. Often, additional tests such as toxicology, histology, and genetic testing will be used to help the pathologist determine the cause of death. Forensic pathologists will often testify in courts regarding their findings in cases of homicide and suspicious death. They also play a large role in public health, such as investigating deaths in the workplace, deaths in custody, as well as sudden and unexpected deaths in children. Forensic pathologists often have special areas of interest within their practice, such as sudden death due to cardiac pathology, deaths due to drugs, or Sudden Infant Death (SIDS), and various others.

• (Also New Zealand, Hong Kong, Singapore, Malaysia, and Saudi Arabia)

Anatomical Pathology is one of the specialty training programs offered by the Royal College of Pathologists of Australasia (RCPA). The

. To qualify as a Fellow of the RCPA in Anatomical Pathology, the candidate must complete a recognised undergraduate or postgraduate medical qualification and then complete a minimum of 2 years of clinical medical experience as a prerequisite to selection as a training registrar. The training program is a minimum of 5 years, served in at least two laboratories, and candidates must pass a Basic Pathological Sciences examination (usually in first year), the Part 1 examinations (not before 3rd year) and the Part 2 examinations (not before 5th year). Fellows may then continue into subspecialty training.

Anatomical Pathology (AP) is one of the specialist certificates granted by the Royal College of Physicians and Surgeons of Canada. Other certificates related to pathology include general pathology (GP), hematopathology, and neuropathology. Candidates for any of these must have completed four years of medical school and five years of residency training.

Anatomic Pathology (AP) is one of the two primary certifications offered by the American Board of Pathology (the other is

To be certified in anatomic pathology, the trainee must complete four years of medical school followed by three years of residency training. Many U.S. pathologists are certified in both AP and CP, which requires a total of four years of residency. After completing residency, many pathologists enroll in further years of fellowship training to gain expertise in a subspecialty of AP or CP. Pathologists' Assistants are highly trained medical professionals with specialized training in Anatomic and Forensic pathology. To become a Pathologists' Assistant one must enter and successfully complete a NAACLS accredited program and pass the ASCP Board of Certification Exam.

Practice settings

• Academic anatomical pathology is practiced at university medical centers by pathologists who are also university faculty. As such, they often have diverse responsibilities that may include training pathology
  medical students, conducting basic, clinical, or translational research
  , or performing administrative duties, all in addition to the practice of diagnostic anatomical pathology. Pathologists in academic settings often sub-specialize in a particular area of anatomic pathology and may serve as consultants to other pathologists regarding cases in their specific area of expertise.
• Group practice is the most traditional private practice model. In this arrangement, a group of senior pathologists will control a partnership that employs junior pathologists and contracts independently with hospitals to provide diagnostic services, as well as attracting referral business from local clinicians who practice in the outpatient setting. The group often owns a laboratory for
  blood banks, clinical chemistry laboratories, and medical microbiology
  laboratories as well.
• Large corporate providers of anatomical pathology services, such as AmeriPath in the United States. In this model, pathologists are employees, rather than independent partners. This model has been criticized for reducing physician independence, but defenders claim that the larger size of these practices allows for economies of scale and greater specialization, as well a sufficient volume to support more specialized testing methods.
• Multispecialty groups, composed of physicians from clinical specialties as well as
  HMO or other large health care organization. In others, they are in essence clinician group practices that employ pathologists to provide diagnostic services for the group. These groups may own their own laboratories, or, in some cases may make controversial arrangements with "pod labs" that allow clinician groups to lease space, with the clinician groups receiving direct insurance payments for pathology services.^[6] Proposed changes to Medicare regulations may essentially eliminate these arrangements in the United States.^[7]

See also

External links

• "Conversations with Pathologists", a website based on a book project by Sue Armstrong, sponsored by Genentech and The Pathological Society of Great Britain and Ireland
• PathReports.in: Make Anatomical pathology reporting paperless and save trees.
• PathMax, a collection of online Pathology resources
• MyBiopsy.org, information on more than 25 of the most common cancers and cancer-related conditions
• The Doctor's doctor, a very useful web site for patients and pathologists
• Pathologie Online, online Pathology resources (in German)
• Pathology Outlines, an online textbook of anatomic pathology
• College of American Pathologists
• American Board of Pathology
• CYTOPATHNET Online Resource Center for Cytopathology
• Histology Group of Victoria Incorporated
• Flickr group: Pathology and Lab Medicine: numerous photos illustrating the work of pathologists.
• Pathtalk.org: A multiple-author weblog by and for anatomic pathologists, with illustrative cases and specialty-related discussions.
• PathologyPics.com: An interactive histology database for the Practicing Anatomic Pathologist as well as Pathology Trainees.