Andrew Fire
Andrew Fire | |
---|---|
Born | Andrew Zachary Fire April 27, 1959 Palo Alto, California |
Alma mater | University of California, Berkeley Massachusetts Institute of Technology |
Known for | RNA interference |
Awards |
|
Scientific career | |
Fields | Pathology, genetics |
Institutions | Johns Hopkins University Stanford University MRC Laboratory of Molecular Biology |
Doctoral advisor | Phillip Allen Sharp |
Notable students | Jenny Hsieh |
Andrew Zachary Fire (born April 27, 1959) is an American
Biography
Andrew-Z-Fire was born in
Fire moved to
From 1986 to 2003, Fire was a staff member of the
Fire is a member of the
Nobel Prize
In 2006, Fire and Craig Mello shared the Nobel Prize in Physiology or Medicine for work first published in 1998 in the journal Nature.[4] Fire and Mello, along with colleagues SiQun Xu, Mary Montgomery, Stephen Kostas, and Sam Driver, reported that tiny snippets of double-stranded RNA (dsRNA) effectively shut down specific genes, driving the destruction of messenger RNA (mRNA) with sequences matching the dsRNA. As a result, the mRNA cannot be translated into protein. Fire and Mello found that dsRNA was much more effective in gene silencing than the previously described method of RNA interference with single-stranded RNA. Because only small numbers of dsRNA molecules were required for the observed effect, Fire and Mello proposed that a catalytic process was involved. This hypothesis was confirmed by subsequent research.
The Nobel Prize citation, issued by Sweden's
It is very unusual for a piece of work to completely revolutionise the whole way we think about biological processes and regulation, but this has opened up a whole new field in biology.[5]
Awards and honors
Fire has received the following awards and honors:
(By chronological year of award [6])
- Meyenburg Prize in 2002
- Co-recipient (with National Academy of SciencesAward in Molecular Biology in 2003
- Co-recipient (with Craig Mello, Thomas Tuschl and David Baulcombe) of the Wiley Prize in the Biomedical Sciences from Rockefeller University in 2003
- Elected member National Academy of Sciencesin 2004
- Co-recipient (with Lewis S. Rosenstiel Awardfor Distinguished Work in Medical Research in 2005
- Co-recipient (with Craig Mello) of the Gairdner Foundation International Awardin 2005
- Co-recipient (with Craig Mello and David Baulcombe) of the Massry Prize in 2005
- Co-recipient (with Craig Mello) of the Paul Ehrlich and Ludwig Darmstaedter Prize in 2006
- Co-recipient (with Craig Mello) of the Nobel Prize in Physiology or Medicine in 2006
See also
References
- ^ a b "Andrew Fire wins 2006 Nobel Prize in Physiology or Medicine". Stanford School of Medicine. 2006-10-02. Archived from the original on 2006-10-10. Retrieved 2006-10-02.
- ^ "Jewish Nobel Prize laureates - Physiology and medicine". www.science.co.il. Retrieved 2023-03-29.
- ^ Shaw, Richard (2007-03-30). "Rejected by Stanford? You'll Live". L.A. Times. Retrieved 21 August 2013.
- S2CID 4355692.
- ^ "Nobel prize for genetic discovery". BBC. 2006-10-02. Archived from the original on 4 October 2006. Retrieved 2006-10-02.
- ^ "UMASS MEDICAL SCHOOL PROFESSOR WINS NOBEL PRIZE". University of Massachusetts Amherst. 2006-10-02. Archived from the original on 2006-12-06. Retrieved 2006-10-02.
External links
- Andrew Z. Fire on Nobelprize.org including the Nobel Lecture Gene Silencing by Double Stranded RNA
- Nobel Prize press release
- Carnegie Institution for Science
- Nobel announcement from Stanford University
- US Patent 6506559 Genetic inhibition by double-stranded RNA (patent)
- Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans, in University of Massachusetts Medical School